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Code:

DRB-00077

Size:

60 VC

MSRP:

$ 17.99

Does Not Contain: milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, salt, or preservatives.

What is it?
Ingredients
Benefits
Safety
Scientific References

Capsule 3

Best 5-HTP (100mg) 60 Veggie Caps

Suitable for vegetarians

Science-Based Nutrition
Dietary Supplement
Helps maintain mental and emotional well-being*

5-HTP (5-hydroxy L-tryptophan) is a naturally occurring metabolite of the amino acid tryptophan. 5-HTP is converted in the brain to serotonin, a neurotransmitter substance found at the junctions (synapses) between neurons. 5-HTP helps maintain mental and emotional well-being and promotes healthy sleep.* Best 5-HTP is extracted from the seeds of the Griffonia simplicifolia plant.

Suggested Adult Use: Take 1 capsule two or three times daily, with or without food.

Caution: Not to be used when taking MAO inhibitors, selective serotonin reuptake inhibitors (SSRIs), or other anti-depressant medications. It should also not be used by individuals taking any of the category of medications known as "triptans". Keep out of reach of children.

Note: Best 5-HTP is tested to ensure that it does not contain "Peak X"

Supplement Facts
Serving Size: 1 Capsule
Servings per container: 60 servings
Amount Per Serving %DV
5-hydroxy L-tryptophan 100 mg †
----------------------------------------------------------------------------------

† Daily Values Not Established.

Other Ingredients: Modified cellulose (vegetarian capsule), rice powder, magnesium stearate (vegetable source).

Contains nothing other than listed ingredients.

100mg, 60VC

5-hydroxytryptophan (5-HTP) is a naturally occurring metabolite of the essential amino acid tryptophan. The 5-HTP in dietary supplements is derived from the seeds of the African plant Griffonia simplicifolia.

5-HTP functions as the precursor for serotonin, a monoamine neurotransmitter found in the central nervous system (CNS) and some cells of the digestive tract. In the body, 5-HTP is formed by the addition of a hydroxyl group (–OH) to tryptophan, a reaction catalyzed by the enzyme tryptophan hydroxylase. This enzyme can be hindered by stress and conditions such as vitamin B6 deficiency, which is one reason B6 is included in this formula. Additionally, pyridoxal phosphate (vitamin B6) is necessary for 5-HTP to be converted to serotonin. Vitamin C participates in the conversion of tryptophan to 5-HTP and of tyrosine to norepinephrine, another important neurotransmitter.

Synthesis of serotonin in the brain requires an adequate supply of either tryptophan or 5-HTP as precursors in the CNS. The supply of tryptophan available for conversion to 5-HTP depends on a number of factors, including the nutritional status of the individual and the competition between tryptophan and other amino acids for transport across the blood-brain barrier. Whereas tryptophan may be sidetracked into the production of niacin or protein, 5-HTP readily crosses the blood-brain barrier and becomes available for serotonin synthesis. Therefore, supplementation with 5-HTP is a more direct route to serotonin production.¹

In contrast to tryptophan, orally consumed 5-HTP is readily absorbed by the mucosal cells of the gastrointestinal tract, with up to 70% then appearing in the bloodstream.² The implications of possibly altering serotonin in this manner are significant: serotonergic neurons (nerve cells stimulated by serotonin) regulate sleep, appetite, nociception (the perception of pain), and aggressive behavior.

Enhances sense of well-being*

A synaptic serotonin deficit is hypothesized to be capable of a major adverse effect on mood.³ Supplementation with 5-HTP therefore is believed to balance mood via an increase in serotonin synthesis. This was researched extensively upon discovery that 5-HTP could be used to alter serotonin levels in rats. In a pilot study on humans, the subjects receiving 5-HTP showed a 35% increase on a mood rating scale, whereas the placebo group showed a 6% decrease.⁴

A comprehensive review of seven open and seven controlled clinical studies found that oral consumption of 5-HTP improved mental and emotional status in 60 to 70 percent of subjects.⁵ The results varied from "modest" to "marked." Dosages ranged from 50 to 300 mg daily.

In a study of 134 recently bereaved men, mood was assessed using the Profile of Mood States (POMS) questionnaire. Men in this study who had adequate pyridoxine (vitamin B6) status had significantly better total mood disturbance (TMD) and confusion-bewilderment subscale scores. Additionally, pyridoxine deficiency was specifically related to a fatigued mood.⁶

Promotes calming down and relaxing*

In a study of 32 healthy adults, half of the subjects were given 200 mg of 5-HTP, and the other half given placebo. All of the subjects were then given a stress-inducing substance (CCK-4) to provoke tension and elicit nervous irritability. In the female subjects who took the 5-HTP, there was a significant reduction in the rate and intensity of the negative cognitive reaction.⁷This research built on previous studies where administration of 5-HTP produced a calming effect in subjects prone to nervous irritability.

Promotes satiety and supports healthy eating patterns*

May promote weight loss as part of a weight loss plan*

An exciting area of research recently regaining attention is the relationship between serotonin and appetite—and therefore its potential to aid in the maintenance of a healthy weight. While serotonin is renown for its function in the brain, 95% of serotonin is actually found in the gastrointestinal tract. Accordingly, serotonin is deeply involved in gut physiology, including visceral perception and weight maintenance.⁸ In research where 5-HTP was administered at higher doses, it was discovered that these high doses of 5-HTP produced weight loss in subjects, mainly through its influence on satiety and an altered appetite for specific macronutrients.

A study that orally administered either 5-HTP or placebo to 19 women for 5 weeks (without any dietary restrictions) resulted in significantly decreased food intake and weight loss in the women taking 5-HTP, compared to placebo.⁹In a double-blind, randomized study, 20 subjects received either 5-HTP capsules or placebo for 6 weeks with dietary restrictions, and then for 6 weeks without dietary restrictions. During both periods (with or without dietary restrictions), the 5-HTP subjects experienced early satiety, a reduction in carbohydrate intake, and significant weight loss compared to placebo.¹⁰ In a subsequent double-blind, randomized study, 11 subjects received placebo and 9 subjects received 5-HTP capsules for 2 weeks. The 5-HTP group experienced weight loss through a significant decrease in carbohydrate and fat intake.¹¹

An animal study took experimental use of 5-HTP a step further by investigating food deprivation and also stress-induced eating. Although the 5-HTP was injected rather than orally administered in the rats, results clearly showed that administration of 5-HTP suppressed eating compared to placebo treatment in food-deprived rats and even more so in rats undergoing stress.¹²

May improve quality of sleep*

Studies have shown that 5-HTP influences the quality of sleep by increasing REM (rapid eye movement) sleep. Administration of as little as 200 mg of 5-HTP in the evening prior to bedtime has been shown to increase the duration of REM sleep from 5 to 53% and decrease the amount of non-REM sleep.¹³

Potent scavenger of free radicals*

Compounds such as vitamin E and flavonoids derive their free-radical quenching ability from their hydroxyl groups (–OH), which donate electrons to oxidants. 5-HTP is formed from tryptophan by the addition of an –OH group, which gives 5-HTP its antioxidant properties. This is in contrast to tryptophan, which is sensitive to oxidation. The effectiveness of 5-HTP in preventing lipid and protein oxidation is believed to contribute to liver cell integrity by countering membrane rigidity.¹⁴ A recent laboratory test demonstrated that 5-HTP is a more effective hydroxyl radical scavenger than even vitamin C.¹⁵

Oral administration of 5-HTP in clinical studies has resulted in gastrointestinal disturbances such as nausea, vomiting and diarrhea. According to a review of several studies, these effects are tolerated by most patients and tend to lessen over time. Side effects are more marked with higher doses.⁵ A recent review in a toxicology journal concludes that while undue speculation was raised years ago, “there is no evidence to implement 5-HTP intake as a cause of any illness.”¹⁶

Notice: Not to be used concurrently with MAO inhibitors, selective serotonin reuptake inhibitors (SSRIs) or other anti-depressant medications. It should also not be used by individuals taking any of the category of medications known as "triptans".

Free of "Peak X" as verified by assay.

Caution: Keep out of reach of children.

Birdsall, T.C., Altern Med Rev, 1998. 3(4): p. 271-80.
5-hydroxytryptophan. Alternative Medicine Review, 1998. 3(3): p. 224-226.
van Praag, H.M. and J. Korf, J Nerv Ment Dis, 1974. 158(5): p. 331-7
Turner, E.H., J.M. Loftis, and A.D. Blackwell, Pharmacol Ther, 2006. 109(3): p. 325-38.
Byerley, W.F., et al., J Clin Psychopharmacol, 1987. 7(3): p. 127-37.
Baldewicz, T., et al., Psychosom Med, 1998. 60(3): p. 297-308.
Maron, E., et al., J Psychopharmacol, 2004. 18(2): p. 194-9.
Hasler, W.L., Curr Gastroenterol Rep, 2009. 11(5): p. 383-91.
Ceci, F., et al., J Neural Transm, 1989. 76(2): p. 109-17.
Cangiano, C., et al., Am J Clin Nutr, 1992. 56: p. 863-867.
Cangiano, C., et al., International Journal of Obesity, 1998. 22: p. 648-654.
Amer, A., et al., Pharmacology Biochemistry and Behavior, 2004. 77(1): p. 137-143.
Wyatt, R.J., et al., Electroencephalogr Clin Neurophysiol, 1971. 30(6): p. 505-9.
Reyes-Gonzales, M.C., et al., J Membr Biol, 2009.
Keithahn, C. and A. Lerchl, J Pineal Res, 2005. 38(1): p. 62-6.
Das, Y.T., et al., Toxicol Lett, 2004. 150(1): p. 111-22.

FAQ's
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Q1.	What is Peak X?
A1.	Some years ago an impurity was found in the raw material from which t-HTP is derived. It was named "Peak X" because, on a certain kind of test, the impurity shows up, but at first no-one knew what it was, so it was named "peak x." The producers of 5-HTP have found a way to eliminate the impurity, and thus there is no longer a "peak x" to be seen on the test.

Q2.	What does 5HTP stand for?
A2.	"5HTP" is the shorthand everyone uses to mean "5 Hydroxy L-Tryptophan." 5HTP is the common, or "street name." The "L" designates the chemical "rotation" of the amino acid.

Q3.	What is modified cellulose and is it safe?
A3.	The cellulose is derived from alpha cellulose from softwood pulp. This softwood pulp may be derived from hemlock, spruce or other soft woods. It is made by cooking raw plant fiber in an aqueous solution to separate the cellulose, and then purified. It then goes through extra processing to further break down the fiber. The finished product contains no residual solvents. Excipients are needed to make the materials flow into the capsule and are extremely minute in amounts and are safe.

Q4.	I am somewhat confused on how to take the DRB products. On many of the labels the Suggested Adult Use will list something along the lines of: Take 2 capsules daily, but it does not state whether they should be taken together or separately. What is the correct usage?
A4.	Unless otherwise specified on the label, the product may be taken together or separately.

Q5.	Is there a limit to how many vitamins can be taken safely in one day?
A5.	While our bodies need vitamins and minerals, like other things, if taken in large amounts they may adversely affect health. Large amounts of anything can be toxic. It is important to follow all label directions and discuss any concerns with your physician.

Q6.	What are the other ingredients and why are they used?
A6.	These are used as flow agents and aid in the production to keep the machinery running smoothly and the capsules filling correctly. Similarly for the croscarmellose sodium, which is cellulose (sourced from the cell walls of green plants), and is used to help disintegrate the tablet in the stomach.

Q7.	Why is silicon dioxide used as an excipient in DRB products?
A7.	Silicon Dioxide is commonly used as a flow agent in supplements. It also works as an anti-caking agent, and is added as an ingredient in foods, many multivitamins and mineral supplements because silicon is necessary for good health and is a necessary nutrient for the health of skin, hair, nails and bones.

Q8.	It seems that information is now out claiming that magnesium stearate is a form of, or implicated in, trans fat, which everyone now regards as being bad. Why does Doctor’s Best use magnesium stearate in its products?
A8.	Magnesium Stearate is used to work as a lubricant in the formula. Magnesium Stearate is a salt of stearic acid. Stearic acid is a saturated fatty acid. A trans fatty acid (commonly shortened to trans fat) is an unsaturated fatty acid molecule. Stearic acid, being a saturated fatty acid, is not a trans fat. The magnesium stearate used in Doctor’s Best products is vegetable sourced from palm oil.

Q9.	What kind of rice constitutes the rice powder excipient commonly used in several DRB products?
A9.	Rice Powder comes from white rice unless otherwise specified on the label.

Q10.	What is cellulose and modified cellulose produced from?
A10.	Southern pine and spruce.

Q11.	Since Doctor's Best does not manufacture its supplements, how are the purity and integrity of supplements verified? In addition, how are your prices lower than other brands? Does this mean that quality is being compromised?
A11.	Doctor's Best supplements are manufactured in the US at cGMP (current Good Manufacturing Practice) certified facilities. All of our manufacturers and suppliers go through our vendor qualification program, which includes inspections and testing, before we agree to work with them. Our finished products have also been tested at the raw material level, in process, and as a finished product to ensure safety and quality. We place the highest importance on safety and quality and do not compromise for the sake of a better price point. The price points are lower because of production size and the overall business structure. We also place great importance on making our supplements available and affordable to those who need them most.

Q12.	What is HPLC?
A12.	HPLC stands for "High Performance Liquid Chromatography." This is an analytical lab testing method that is used to quantify the active ingredients. It is considered to be a very sensitive and accurate test. HPLC testing is a tool recognized as a quality benchmark for herbal extracts.

Q13.	Does cellulose interfere with the absorption of supplements?
A13.	Dietary fiber in general is known to change intestinal viscosity, nutrient absorption, transit time, and gut hormones. Although there is some evidence from animal studies that large amounts of cellulose in the diet (6-12% of diet) can interfere with nutrient absorption (particularly minerals), there is no evidence that the small amount in capsules interfere with nutrient absorption, as there are many pharmacokinetic studies that have been conducted with nutrients in cellulose capsules, demonstrating the ability of the nutrients to be effectively absorbed.

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