Best Muscadine Grape Seed (700mg) 120 Veggie Capsules
Suitable for vegetarians
Science-based nutrition
Dietary supplement
Premier antioxidant & tissue protector*
Potent antioxidant protection*
Scavenges free radicals and protects tissue health*
Muscadine grapes, native to the southeastern United States, are renowned as a great source of antioxidant compounds. Muscadine grapes grew wild in wooded areas and were enjoyed for their nutritional benefits by Native Americans hundreds of years ago. They were subsequently introduced to European settlers who proceeded to cultivate the fruit. The seeds of Muscadine grapes are loaded with compounds that support health including phenolic compounds such as ellagic acid, oligomeric proanthocyanidins (OPCs), resveratrol and quercetin.* Muscadine grapes grow and thrive in the difficult, hot and humid climate of the southeastern United States, making them an especially rich source of these free radical scavenging phytochemicals.* Suggested Use: As a dietary supplement, take 1 capsule daily with or without food, or as directed by a physician.
Supplement Facts Serving Size: 1 capsule Serving per container: 120 servings Amount Per Serving %DV Muscadine Grape Seed 700mg † (Vitis rotundifolia) (provides an average ORAC value of 31,800 μmol/100g) ---------------------------------------------------------------------------------------------------------- * % Daily Value based on a diet supplying 2000 calories per day. † Daily Value not established Other Ingredients: Modified cellulose (vegetarian capsule, rice powder, magnesium stearate (vegetable source), silicon dioxide.
Contains nothing other than listed ingredients.
700mg, 120VC
Muscadine grapes are native to the southeastern United States and are renowned as a plentiful source of antioxidant compounds. These grapes grew wild in wooded areas and were enjoyed for their nutritional benefits by Native Americans centuries ago. They were subsequently introduced to European settlers who proceeded to cultivate the fruit, leading to today's designation of this fruit as "America's first grape." The seeds of Muscadine grapes are loaded with compounds that support health including phenolic compounds such as ellagic acid, oligomeric proanthocyanidins (OPCs), resveratrol and quercetin.* Muscadine grapes grow and thrive in the difficult, hot and humid climate of the southeastern United States, making them an especially rich source of these free radical scavenging phytochemicals.*
Antioxidant Regeneration and Promotion of Cellular Health*
Oxidative stress is part of daily life, and antioxidants can ease the burden of free radical damage. Plants yield a number of beneficial phytochemicals, including classes of compounds that can counter oxidative stress in the body. Phenolic compounds are among these, and grapes have been widely studied because of polyphenols like quercetin and resveratrol that are found in them. Numerous studies have demonstrated the contributions of bioflavonoids towards the maintenance of a healthy metabolism and, consequently, ideal organ function. Muscadine grape seeds contain a spectrum of important phenolic compounds, including gallic acid and many flavonoids. Researchers have found that the phenolic content of muscadine grape seeds is on average 5 times greater than in the grape skins and 80 times greater than in the pulp.1
Muscadine grape seeds are most abundant in gallic acid and the flavonols catechin and epicatechin, but also contain a number of larger procyanidins, including oligomeric proanthocyanidins (OPCs). While all of these compounds have been shown to scavenge free radicals in vitro, a recent study concluded that the superior antioxidant capacity of grape seeds is mainly from their larger procyanidins, such as the OPCs.2 Oligomeric cyanidins have several means of counteracting oxidative stress and can be more effective than commercially available antioxidant supplements like vitamins C & E.3
In regard to cellular health, the type of flavonoids found in grape seeds (such as catechin and epicatechin) are thought to aid in stopping the oxidation chain reaction of lipids that damage cell integrity, with one study concluding that tannins (another type of polyphenol in grape seeds) may be as important as vitamin E in terms of this activity.4 A diet high in catechin-rich foods and beverages has been correlated with enhanced maintenance of cardiovascular function.5 Since catechin monomers and oligomeric procyanadins (OPCs) are complementary and synergisitic in their ability to neutralize different types of free radical species, it is thought that food sources containing a combination of both monomers and OPCs (as grape seeds do) will offer a greater array of protection against oxidative stress in the body. Biologically relevant levels of these compounds can be achieved in vivo from foods containing catechins, epicatechins, and OPCs,6 or from extracts of foods such as Muscadine grapes.
While there is no substitute for eating the recommended daily servings of fruits and vegetables, supplementation with derivatives of plants such as muscadine grape seeds can help increase daily intake of important phenolic compounds.
Does Not Contain: milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, salt, or preservatives.
Pastrana-Bonilla, E., et al., Phenolic content and antioxidant capacity of muscadine grapes. J Agric Food Chem, 2003. 51(18): p. 5497-503. Click here for study.
Yilmaz, Y. and R.T. Toledo, Major flavonoids in grape seeds and skins: antioxidant capacity of catechin, epicatechin, and gallic acid. J Agric Food Chem, 2004. 52(2): p. 255-60. Click here for study.
Ariga, T., The antioxidative function, preventive action on disease and utilization of proanthocyanidins. Biofactors, 2004. 21(1-4): p. 197-201. Click here for study.
Yilmaz, Y. and R.T. Toledo, Health aspects of functional grape seed constituents. Trends in Food Science & Technology, 2004. 15: p. 422-433. Click here for study.
Muzolf, M., et al., pH-Dependent radical scavenging capacity of green tea catechins. J Agric Food Chem, 2008. 56(3): p. 816-23. Click here for study.
Lotito, S.B., et al., Influence of oligomer chain length on the antioxidant activity of procyanidins. Biochem Biophys Res Commun, 2000. 276(3): p. 945-51. Click here for study.
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