Best trans-Resveratrol featuring ResVinol-25 60 Veggie Caps
Suitable for Vegetarians
Science-based nutrition
Dietary supplement
High-potency resveratrol formulation
Best trans-Resveratrol 100 features ResVinol-25™, a proprietary extract providing concentrated levels of polyphenols and trans-resveratrol from red wine matrix and the root of the Japanese knotweed (Polygonum cuspidatum) plant. Resveratrol exists in both trans- and cis-forms. However, published research suggests that only the trans- form has valuable biological activity.
ResVinol-25™ is a high-quality extract subjected to rigorous ProfileProven™ analytical and quality assurance procedures designed to ensure potency and purity of the extract from batch to batch. The product is extensively tested for heavy metals, bacterial and fungal contaminants, and pesticides to verify purity and compliance with acceptable standards.
Suggested Adult Use: Take 1 or more capsules daily with meals.
Supplement Facts Serving Size: 1 capsule Servings Per Container: 60 servings Amount Per Serving % DV trans-Resveratrol 100 mg † ------------------------------------------------------------------------------------------------- Polyphenols 80 mg † (from red wine matrix (Grape (Vitis vinifera)) and Japanese Knotweed (Polygonum cuspidatum)) ------------------------------------------------------------------------------------------------- † Daily Value not established.
Other ingredients: Rice flour, silicon dioxide, magnesium stearate (vegetable source).
Contains nothing other than listed ingredients.
100mg, 60VC
Best trans-Resveratrol features ResVinol-25™, a proprietary extract providing concentrated levels of polyphenols and trans-resveratrol from red wine matrix and the root of the Japanese knotweed (Polygonum cuspidatum) plant. Designed to ensure potency and purity of the extract from batch to batch, ResVinol-25™ is a high-quality extract subjected to rigorous ProfileProven™ analytical and quality assurance procedures. The product is extensively tested for heavy metals, bacterial and fungal contaminants, and pesticides to verify purity and compliance with acceptable standards.
Resveratrol (3, 4', 5-trihydroxystilbene) is a naturally occurring compound that belongs to a group of non-flavonoid polyphenols called stilbenes. Interest in potential health benefits for humans was spurred upon observation of resveratrol being produced by grapevines (and other plants) in response to stress, UV radiation, and microbial attacks.1
Supports Immune System Function* Promotes a Normal, Balanced Inflammatory Response*
A summary report on resveratrol noted that its ability to modulate immune function and promote a balanced inflammatory response works not through one simple mechanism, but through several complex pathways.2 As shown in mice, resveratrol inhibited the TNF-alpha cytokine pathways that are critical in regulation of immune cells. Resveratrol can inhibit inflammatory enzymes and the synthesis of pro-inflammatory mediators and eicosanoids.3-5 In mouse mast cells, resveratrol inhibited TNF-alpha and histamine release, in turn blocking production of unfavorable eicosanoids. In lung cells, resveratrol appears to inhibit macrophage release of IL-8 chemokines in vitro, limiting overreaction of white blood cells.6 An in vitro study conducted with human polymorphonuclear leukocytes (or PMN-L, a type of white blood cell) showed that even tiny amounts of resveratrol specifically inhibited the formation of pro-inflammatory metabolites of arachidonic acid.7
Supports Cardiovascular Health*
Enhances Cerebral Circulation*
The “French Paradox” has led to extensive research into the physiological effects of the bioactive components of red wine—the active ingredients in Best trans-Resveratrol. To build on evidence of the potent cardiovascular effects of resveratrol seen in animal studies, the focus has now shifted to working with human samples. In 20 healthy adults examined before and after 15 days of controlled wine consumption, an increase in blood nitric oxide (NO) production was reported.8 Nitric oxide is a gas responsible for signaling the smooth muscle in blood vessels to relax, thus promoting healthy circulatory function. In a particularly convincing study using blood vessel tissue derived from humans, resveratrol promoted nitric oxide-induced vascular relaxation and overall enhanced endothelial (blood vessel) function.9
Results from a cutting-edge crossover study published in 2010 provide exciting new evidence of other possible benefits of resveratrol supplementation. In this randomized, double-blind, placebo-controlled investigation, 22 healthy adults each received placebo, 250mg trans-resveratrol, and 500mg trans-resveratrol on separate days. In a dose-dependent fashion, supplementation with trans-resveratrol resulted in higher cerebral blood flow in the prefrontal cortex during cognitive tasks (compared to placebo). The researchers also measured the bioavailability of their supplements, confirming that resveratrol and its metabolites were present in the blood following supplementation at both doses. They concluded that resveratrol, when taken orally, can influence brain function.10
Facilitates Potent Antioxidant Activity*
Supports the Integrity and Activity of Neuronal Cells*
Although the mechanisms behind all its actions are not yet fully understood, resveratrol is revered for its antioxidant functions. Scientists do know that resveratrol counters lipid peroxidation both by the chelation of copper and the quenching of free radicals. In one of many in vitro trials investigating its antioxidant functions, trans-resveratrol worked at 95% efficiency to deter lipid peroxidation. Under the same oxidative stress load, vitamins E and C worked at efficiencies of only 65% and 37%, respectively.11 In a 2010 study, researchers observed resveratrol’s action on erythrocytes (red blood cells) derived from 23 healthy volunteers. When the erythrocytes were subjected to oxidative stress, resveratrol protected the cell glutathione levels—evidence of protection from oxidative stress.12
Numerous studies have examined the role of resveratrol in protecting the nervous system from oxidative damage. In one such study the researchers examined resveratrol’s action on in vitro brain cell samples and noted less depletion of the antioxidant glutathione, less accumulation of oxidative agents, and less neuronal damage. These scientists also noted a protective role from sirtuin activity, revealing that the benefits of resveratrol in this scenario can be multifactorial.13 In a recent study, resveratrol prevented an increase in acetylcholinesterase activity in rats, which helped preserve their cognitive function—memory in particular. These observations led to conclusions that resveratrol may help ameliorate oxidative stress that occurs in several areas of the brain, thereby influencing neurotransmission.14 Several previous studies, such as one showing preserved cognitive function in rats (presumably from resveratrol’s antioxidant activity), build a strong case for the usefulness of resveratrol in supporting brain function in mammals.15
Promotes Healthy Aging*
May Enhance Healthy Glucose Metabolism*
Perhaps the most intriguing aspect of resveratrol activity is its apparent ability to increase the longevity of numerous species—ranging from simple organisms, like yeast, to those with complex genomes, like mice. In several organisms, both caloric restriction and resveratrol consumption have demonstrated the ability to activate sirtuins, a group of proteins that have been linked to aging, metabolism, and cellular stress tolerance.16, 17 Activation of sirtuins is a proposed mechanism behind resveratrol’s apparent ability to extend the lifespan of yeast, worms, fruit flies, and vertebrate fish. Since dietary restriction in humans can in many respects lead to a higher quality of life during the aging process, the prospect of a compound that mimics this dietary restriction garners great attention in the scientific community.
A groundbreaking study published in 2006 demonstrated the ability of resveratrol to shift the physiology of mice consuming excess calories (including some of the health concerns instigated by excessive diets) to one of mice consuming a standard diet—all without significant changes in body weight. In simpler terms, the resveratrol enabled the overeating mice to have a level of health enjoyed by mice that ate a proper diet.18 In a subsequent study using mice, researchers concluded that resveratrol seemed to mimic the effect of a restricted-calorie diet at the transcriptional (genetic) level, and was able to benefit tissues of the heart, liver, and muscle in a manner similar to dietary restriction.19 These results are reinforced by yet another study where researchers found that, in mice, a low dose of resveratrol mimicked the effects of a restricted-calorie diet on gene expression in vital organs that affect aging; however, the researchers concluded that in this case it was due to factors other than influence on sirtuins.20 More research is needed to fully comprehend how resveratrol works, but the volumes of papers published attest to the multifaceted wonders of resveratrol and its companion red wine phenolic compounds.
Lastly, it should be mentioned that a good deal of interest has been generated by the apparently favorable actions of resveratrol on glucose metabolism, as seen in animal studies.21,22 A recent in vitro study demonstrated trans-resveratrol’s influence on how skeletal muscle responds to glucose, presumably through the action of sirtuins.23 Furthermore, a 2010 in vitro resveratrol study even shows positive metabolic interactions with human fat cells.24 While the implications of results like these are provoking, clinical trials need to be conducted to determine the degree of practicality for such uses of resveratrol.
In sum, more research is needed to fully comprehend how resveratrol works inside the human body, but the volumes of in vitro and in vivo data attest to the multifaceted potential of the compounds found in a bottle of Best trans-Resveratrol.
Most studies have shown that resveratrol is rapidly absorbed and metabolized in humans. In a 2010 review of safety data from human studies that administered resveratrol at high doses, no serious side effects were reported.25 Although long-term data is not available for humans, long-term resveratrol supplementation at moderate to high (but not extremely high) doses in rodents did not produce side effects.19,26 Because human research is limited, pregnant women should check with a physician prior to using the product.
Bagchi, D., 2000, Los Angeles, CA: Keats Publishing. 72.
de la Lastra, C.A. and I. Villegas, Mol Nutr Food Res, 2005. 49(5): p. 405-30.
Martinez, J. and J.J. Moreno, Biochemical Pharmacology, 2000. 59(7): p. 865-870.
Subbaramaiah, K., et al., Journal of Biological Chemistry, 1998. 273(34): p. 21875-21882.
de la Lastra, C.A. and I. Villegas, Biochem Soc Trans, 2007. 35(Pt 5): p. 1156-60.
Donnelly, L.E., et al., Am J Physiol Lung Cell Mol Physiol, 2004. 287(4): p. L774-83.
Kimura, Y., H. Okuda, and M. Kubo, Journal of Ethnopharmacology, 1995. 45(2): p. 131-139.
Gresele, P., et al., J Nutr, 2008. 138(9): p. 1602-8.
Rakici, O., et al., Int J Cardiol, 2005. 105(2): p. 209-15.
Kennedy, D.O., et al., Am J Clin Nutr, 2010. 91(6): p. 1590-7.
Stojanovic, S., H. Sprinz, and O. Brede, Arch Biochem Biophys, 2001. 391(1): p. 79-89.
Pandey, K. and S. Rizvi, Phytother Res, 2010. 24: p. 11-14.
Okawara, M., et al., Biochem Pharmacol, 2007. 73(4): p. 550-60.
Schmatz, R., et al., Eur J Pharmacol, 2009. 610(1-3): p. 42-8.
Kumar, P., et al., Behav Pharmacol, 2006. 17(5-6): p. 485-92.
Calabrese, V., et al., Neurochem Res, 2008. 33(12): p. 2444-71.
Baur, J.A. and D.A. Sinclair, Nat Rev Drug Discov, 2006. 5(6): p. 493-506.
Baur, J.A., et al., Nature, 2006. 444(7117): p. 337-342.
Pearson, K.J., et al., Cell Metab, 2008. 8(2): p. 157-68.
Barger, J.L., et al., PLoS ONE, 2008. 3(6): p. e2264
Palsamy, P. and S. Subramanian, Biomed Pharmacother, 2008. 62(9): p. 598-605.
Szkudelski, T., Am J Physiol Endocrinol Metab, 2007. 293(4): p. E901-7.
Breen, D.M., et al., Biochem Biophys Res Commun, 2008. 374(1): p. 117-22.
Fischer-Posovszky, P., et al., Am J Clin Nutr, 2010. 92(1): p. 5-15.
Cottart, C.H., et al., Mol Nutr Food Res. 54(1): p. 7-16.
Juan, M.E., M.P. Vinardell, and J.M. Planas, J Nutr, 2002. 132(2): p. 257-60.
The cellulose is derived from alpha cellulose from softwood pulp. This softwood pulp may be derived from hemlock, spruce or other soft woods. It is made by cooking raw plant fiber in an aqueous solution to separate the cellulose, and then purified. It then goes through extra processing to further break down the fiber. The finished product contains no residual solvents. Excipients are needed to make the materials flow into the capsule and are extremely minute in amounts and are safe.
Q2.
I am somewhat confused on how to take the DRB products. On many of the labels the Suggested Adult Use will list something along the lines of: Take 2 capsules daily, but it does not state whether they should be taken together or separately. What is the correct usage?
A2.
Unless otherwise specified on the label, the product may be taken together or separately.
Q3.
Is there a limit to how many vitamins can be taken safely in one day?
A3.
While our bodies need vitamins and minerals, like other things, if taken in large amounts they may adversely affect health. Large amounts of anything can be toxic. It is important to follow all label directions and discuss any concerns with your physician.
Q4.
What are the other ingredients and why are they used?
A4.
These are used as flow agents and aid in the production to keep the machinery running smoothly and the capsules filling correctly. Similarly for the croscarmellose sodium, which is cellulose (sourced from the cell walls of green plants), and is used to help disintegrate the tablet in the stomach.
Q5.
What is Silicon Dioxide and how is it produced?
A5.
Silicon dioxide is the most abundant mineral in the Earth’s crust, and it is found across the world in various forms. Silicon dioxide (SiO2) in its pure form is colorless to white. Precipitated synthetic amorphous silicas are obtained from a process essentially using sand.
Precipitated silica is a safe (non-crystalline) mineral. According to the relevant United States and European Union standards, precipitated silica is non-hazardous with regard to manufacture, transportation and handling. Precipitated silica is an inert powder and a certified food and feed additive.
Q6.
Should I be concerned when I see that Silicon Dioxide has been used as an excipient in DRB products?
A6.
According to numerous studies reviewed to date on this long-term Generally Recognized As Safe (GRAS) listed food additive, the following was found:
The oral toxicity in mice is greater than (>) 5 grams/kilogram of body weight (Kimmerle 1968), or greater than 350 grams in one dose in humans based on allometric comparisons between mice and humans.
A single dose of 2.5 grams of amorphous polymeric silicon dioxide to human volunteers did not significantly raise the SiO2 excretion in the urine thus suggesting poor absorption of the compound (silicon dioxide)--(Langendorf 1966). Less than one one-hundredth (1000th) of the dose was found in urine, suggesting extremely poor absorption--(Langendorf 1966).
This would suggest that there is no scientific reason to eliminate silicon dioxide as an excipient at the very low levels found in dietary supplements.
For further information re: Silicon dioxide, see "Minerals, Trace Elements and Human Health, 4th Edition."
Q7.
Why is silicon dioxide used as an excipient in DRB products?
A7.
Silicon Dioxide is commonly used as a flow agent in supplements. It also works as an anti-caking agent, and is added as an ingredient in foods, many multivitamins and mineral supplements because silicon is necessary for good health and is a necessary nutrient for the health of skin, hair, nails and bones.
Q8.
It seems that information is now out claiming that magnesium stearate is a form of, or implicated in, trans fat, which everyone now regards as being bad. Why does Doctor’s Best use magnesium stearate in its products?
A8.
Magnesium Stearate is used to work as a lubricant in the formula. Magnesium Stearate is a salt of stearic acid. Stearic acid is a saturated fatty acid. A trans fatty acid (commonly shortened to trans fat) is an unsaturated fatty acid molecule. Stearic acid, being a saturated fatty acid, is not a trans fat. The magnesium stearate used in Doctor’s Best products is vegetable sourced from palm oil.
Q9.
Since Doctor's Best does not manufacture its supplements, how are the purity and integrity of supplements verified? In addition, how are your prices lower than other brands? Does this mean that quality is being compromised?
A9.
Doctor's Best supplements are manufactured in the US at cGMP (current Good Manufacturing Practice) certified facilities. All of our manufacturers and suppliers go through our vendor qualification program, which includes inspections and testing, before we agree to work with them. Our finished products have also been tested at the raw material level, in process, and as a finished product to ensure safety and quality. We place the highest importance on safety and quality and do not compromise for the sake of a better price point. The price points are lower because of production size and the overall business structure. We also place great importance on making our supplements available and affordable to those who need them most.
Q10.
What is HPLC?
A10.
HPLC stands for "High Performance Liquid Chromatography." This is an analytical lab testing method that is used to quantify the active ingredients. It is considered to be a very sensitive and accurate test. HPLC testing is a tool recognized as a quality benchmark for herbal extracts.
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