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Code:

DRB-00228

Size:

180C

MSRP:

$ 59.99

Does Not Contain: milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, salt, or preservatives.

What is it?
Ingredients
Benefits
Safety
Scientific References

Capsule 00

Best Hyaluronic Acid with Chondroitin Sulfate 180 Caps

Science-based nutrition
Dietary supplement
Supports healthy joints*
Supports youthful skin*

Best Hyaluronic Acid wth Chondroitin Sulfate contains patented BioCell Collagen II^® (US patents 6,025,327; 6,323,319; & 6,780,841). BioCell Collagen II^® is sourced from chicken sternal cartilage and provides bioavailable, low molecular weight hyaluronic acid. It is standardized to contain 10% Hyaluronic Acid, 20% Chondroitin Sulfate, and 60% Collagen Type II.

Hyaluronic Acid and Collagen are vital structural components of the skin that decline as we age, and are partly responsible for the skin's moisture, suppleness and elasticity. BioCell Collagen II^® contains key components that can help support healthy skin and joint function*.

Suggested Adult Use: Take 2 capsules daily, or as directed by a health care practitioner. Take with 8-10 ounces of water, with or without food.

Serving Size: 2 capsules
Servings Per Container: 90 Servings
Amount Per Serving               %DV
BioCell Collagen II^®, providing:                     1000 mg                   †
Hyaluronic Acid                                                100 mg                   †
Chondroitin Sulfate                                         200 mg                   †
Hydrolyzed Collagen Type II                          600 mg                   †
--------------------------------------------------------------------------------------
† Daily Value not established.

Other Ingredients: Rice powder, gelatin (capsule), magnesium stearate (vegetable source).

Contains nothing other than listed ingredients.

180C

Best Hyaluronic Acid with Chondroitin Sulfate features BioCell Collagen®, a patented, award-winning ingredient derived from a naturally occurring matrix of constituents that is standardized to 20% Chondroitin Sulfate (CS) and 10% Hyaluronic Acid (HA), in addition to approximately 60% Collagen Type II. It is exceptional compared to other collagen-based ingredients due to its very low molecular weight, glycosaminoglycan content, and other advantageous qualities not seen in simple collagen ingredients.

BioCell Collagen® is sourced from the sternal cartilage of chickens that are raised without hormones or steroids present in the poultry feed.

BioCell Collagen® is hydrolyzed and denatured to low molecular weight compounds that increase the bioavailability and absorption of its components. In an absorption study of BioCell Collagen®, measurements revealed a gradual and significant increase of active total Hyaluronic Acid (HA) in the blood of test subjects after a single dose.¹ In the same study, subjects taking BioCell Collagen® for 28 days maintained elevated blood levels of HA compared to initial levels.

The components of Best Hyaluronic Acid with Chondroitin Sulfate are naturally found in human cartilage, and they have all been the topics of intense research in joint health over the past few decades. Collagen and hyaluronic acid are also vital structural components of skin that decline as we age, influencing our skin’s moisture, suppleness, and elasticity. BioCell Collagen® can help replenish the body’s natural supply of these components, which in turn can support healthy skin and joint function.

Hyaline Cartilage: Of Particular Interest As We Age

Acting as an efficient load-bearing surface for our freely movable synovial joints, articular (or hyaline) cartilage becomes a point of concern as we age: As a part of normal physiology, the tensile properties of this cartilage begin to decline after about age 30.² Many factors come into play when considering healthy mechanical function of this invaluable tissue, not the least of which is structural composition.³ Hyaline cartilage is composed mainly of water, proteoglycans, and collagen (primarily Type II collagen). Attached to the protein core of proteoglycans are the glycosaminoglycans keratan sulphate and chondroitin sulfate, which have the important function of binding large amounts of water to work against cartilage compression. The proteoglycans can bind to a hyaluronic acid backbone to form larger molecules, adding to the solid portion of articular cartilage—essentially a dense network of type II collagen fibers embedded in a highly concentrated matrix of aggregate proteoglycan molecules.

Supports Healthy Joint Structure and Function*

Components of BioCell Collagen® (collagen type II, chondroitin sulfate, and hyaluronic acid) can enhance the normal production of proteoglycans in the joint matrix, thereby enhancing healthy joint structure and helping to maintain joint shock absorption and cushioning. In a randomized, double-blind, placebo-controlled pilot study exploring the safety and effectiveness of BioCell Collagen® towards joint health, 16 subjects were enrolled to receive 2 grams of BioCell or placebo daily for 8 weeks.⁴ The subjects who were administered BioCell demonstrated significantly greater joint comfort, mobility, and quality of life over time, compared with placebo.

Collagen Type II

The benefits of collagen type II in safely supporting healthy joint and skin function have been examined in both animal and clinical studies.⁵ A randomized controlled trial conducted on 60 volunteers found that oral administration of chicken collagen type II for 3 months led to a significant increase in healthy joint structure, as compared to no measurable improvement in the placebo group.⁶ In another double-blind, placebo-controlled trial, 274 individuals were given collagen type II orally for 24 weeks. The supplement was shown to support healthy joint function, and no adverse effects were observed during this comprehensive clinical trial.⁷Other studies have shown that hydrolyzed collagen provides a substantial advantage in bioavailability over non-hydrolyzed collagen, thereby having the potential to enhance healthy joint structure more efficiently.⁸

Chondroitin Sulfate

Chondroitin has been extensively researched for its ability to help maintain joint structure and function. In a review of high quality studies that included 1,443 research volunteers, long-term administration of oral chondroitin sulfate promoted knee comfort and overall motility, while also proving to be safe and well tolerated.⁹ On a biochemical level, chondroitin sulfate is believed to supply building blocks for proteoglycan synthesis and to hinder matrix metalloproteases (MMP) that are key proteases capable of degrading a range of matrix components in cartilage.10 Although the methods of action are not yet fully understood, the positive effects of chondroitin sulfate on the chondrocytes (cartilage cells), synovial membranes, and subchondrial bone of joints have been demonstrated in research. The immunomodulatory effects in articular cartilage, such as inhibiting activation of the transcription factor NF-kB, appear to be a primary action by which chondroitin enhances joint comfort.¹¹

Hyaluronic Acid

Hyaluronic Acid (HA) is a type of building block called a glycosaminoglycan, and it plays an important role in supporting the structural strength of connective tissue and cartilage. Healthy connective tissue and cartilage maintenance is fundamental in normal skin and joint function. HA is highly concentrated in synovial fluid, where it serves to enhance joint lubrication and the elastic structural and functional characteristics of the joint. In 2007, a study with 98 participants determined that a healthy concentration of HA in synovial fluid is a strong indicator of joint health.¹² Since the body’s supply of HA naturally decreases with age, Best Hyaluronic Acid with Chondroitin Sulfate has been formulated to help maintain healthy HA levels, allowing for the extended maintenance of joints and skin.

Helps Maintain Youthful Skin*

HA also plays an important role in maintaining the health and natural beauty of the skin. The compound enhances the structure and volume of the skin by promoting healthy connective tissues that interact with the skin. HA plays a direct role in the attraction and maintenance of moisture in the skin; as HA concentrations naturally decrease in the elderly, it may become difficult for the skin to retain moisture, leaving the skin dry and uncomfortable.¹³ Researchers have performed comparative measurements of hyaluronic acid levels in the skin of young and elderly individuals. Results indicate that there is a normal and progressive reduction in the number of hyaluronic acid granules in human skin with age—so much of a reduction, in fact, that a complete absence of these granules was seen in healthy individuals 60 years or older. These variations in HA levels with age may account for the decreased turgidity, wrinkled appearance, and altered elasticity of skin tissue.¹⁴ Recent in-vitro laboratory studies are now indicating that HA not only provides moisture retention and structural support to the skin, but also promotes cellular vitality. The results of one such study indicate that HA given to human epidermal (skin) cells induces cell signaling that promotes natural cell repair and tissue renewal.¹⁵

BioCell Collagen® achieved GRAS (Generally Recognized As Safe) self-affirmation, meaning that a consensus on safety was reached by an independent expert panel of qualified scientists who carried out an extensive review of all available scientific safety data on this ingredient.

The BioCell Collagen® in Best Hyaluronic Acid with Chondroitin Sulfate provides a safe, natural, standardized source of building blocks useful for maintaining joint structure and function, as well as promoting the integrity of healthy skin.

Judy, W., W. Stogsdill, and J. Judy, BioCell Technology. p. 1-22. Unpublished.
Poole, A.R., et al., Ann Rheum Dis, 2002. 61 Suppl 2: p. ii78-81.
Mansour, J., 2004, Lippincott Williams & Wilkins: Baltimore. p. 14.
Pezzullo, J., et al., 2003, Georgetown University. p. 1-13. Unpublished.
Schauss, A.G., et al., Food Chem Toxicol, 2007. 45(2): p. 315-21.
Trentham, D.E., et al., Science, 1993. 261(5129): p. 1727-30.
Barnett, M.L., et al., Arthritis Rheum, 1998. 41(2): p. 290-7.
Moskowitz, R.W., Semin Arthritis Rheum, 2000. 30(2): p. 87-99.
Uebelhart, D., Osteoarthritis Cartilage, 2008. 16 Suppl 3: p. S19-21.
Monfort, J., et al., Ann Rheum Dis, 2008. 67(6): p. 735-40.
du Souich, P., et al., J Cell Mol Med, 2009. 13(8A): p. 1451-63.
Turan, Y., et al., Clin Rheumatol, 2007. 26(8): p. 1293-8.
Beasley, K.L., M.A. Weiss, and R.A. Weiss, Facial Plast Surg, 2009. 25(2): p. 86-94.
Ghersetich, I., et al., Int J Dermatol, 1994. 33(2): p. 119-22.
Neuman, M.G., et al., Clin Biochem, 2010.

FAQ's
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Q1.	Is it OK to take Collagen Type 2 with Collagen Types 1 and 3, or do they compete with each other for absorption?
A1.	They do not compete. To some extent, both would be digested in the GI tract and provide building blocks to the body for connective tissue support. Type I is the most abundant collagen in the body and is in high concentrations in blood vessels, tendons, skin and muscle tissue. Type III is used by the body for quick repairs and is often a precursor to type I. Type II is the major component of hyaline cartilage in joint tissue. Taking all together would likely yield an increase in the building blocks that are needed by the body to support connective tissue in many different areas.

Q2.	How soon will I see results supplementing with collagen?
A2.	How soon an individual may get intended joint or skin health benefits should vary. However, clinical studies of BioCell Collagen and anecdotal evidence support that consumers can start to observe the results in several weeks although they sometimes see difference earlier.

Q3.	After taking the HA for 4 days, a problem seems to be an excessive amount of gas. Today I did not take any HA, and have not had any gas problems. I am allergic to both eggs & milk. Is this contained in the HA? Any possible suggestions on remedying this matter?
A3.	There is no milk or eggs in the product. It is made from chicken trachea cartilage. The Excipients include rice powder and gelatin from animal hides. Hydrochloric acid can be taken along with the Hyaluronic acid as a test to see if poor digestion of the ingredients is to blame for the gas.

Q4.	Is Chondroitin sodium-free?
A4.	No, it does contain a small amount of sodium. Sodium must be added during processing. Glucosamine/Chondroitin/MSM contains just 14 mg of sodium per capsule.

Q5.	What are your gelatin capsules made of?
A5.	Our capsules are typical gelatin capsules, with the exception of select products now available in veggie cap form. See veggie cap listing. They are made of gelatin from cattle, like the “Knox gelatin” sold in grocery stores. The gelatin used to make Doctor’s Best’s capsules is manufactured in accordance with strict guidelines that ensure it is BSE-free. The FDA and the supplement industry approved these guidelines. Our gelatin is made only from cattle living in non-BSE countries. All Doctor’s Best capsules are in full compliance with the FDA’s September 1997 guidance for industry for “The Sourcing and Processing of Gelatin to Reduce the Potential Risk Posed by Bovine Spongiform Encephalopathy in FDA-Regulated Products for Human Use.”

Q6.	How long would it take for a CAPSULE to dissolve?
A6.	Approximately 30-45 minutes. For 2-piece gelatin capsule, the USP standard for maximum dissolution time is 45 minutes. According to one large encapsulator, gelatin capsules typically dissolve in about 30 minutes, but never more than 45 minutes. Note: Testing dissolution times of capsules and tablets at home using vinegar is not an accurate way to learn what happens to capsules and tablets in your stomach. Because stomach acid is much stronger than vinegar, capsules and tablets dissolve much faster in the stomach than in a glass of water or vinegar. Also, the stomach continually “agitates” the content much like a washing machine does.

Q7.	I am somewhat confused on how to take the DRB products. On many of the labels the Suggested Adult Use will list something along the lines of: Take 2 capsules daily, but it does not state whether they should be taken together or separately. What is the correct usage?
A7.	Unless otherwise specified on the label, the product may be taken together or separately.

Q8.	Is there a limit to how many vitamins can be taken safely in one day?
A8.	While our bodies need vitamins and minerals, like other things, if taken in large amounts they may adversely affect health. Large amounts of anything can be toxic. It is important to follow all label directions and discuss any concerns with your physician.

Q9.	What are the other ingredients and why are they used?
A9.	These are used as flow agents and aid in the production to keep the machinery running smoothly and the capsules filling correctly. Similarly for the croscarmellose sodium, which is cellulose (sourced from the cell walls of green plants), and is used to help disintegrate the tablet in the stomach.

Q10.	It seems that information is now out claiming that magnesium stearate is a form of, or implicated in, trans fat, which everyone now regards as being bad. Why does Doctor’s Best use magnesium stearate in its products?
A10.	Magnesium Stearate is used to work as a lubricant in the formula. Magnesium Stearate is a salt of stearic acid. Stearic acid is a saturated fatty acid. A trans fatty acid (commonly shortened to trans fat) is an unsaturated fatty acid molecule. Stearic acid, being a saturated fatty acid, is not a trans fat. The magnesium stearate used in Doctor’s Best products is vegetable sourced from palm oil.

Q11.	What kind of rice constitutes the rice powder excipient commonly used in several DRB products?
A11.	Rice Powder comes from white rice unless otherwise specified on the label.

Q12.	Since Doctor's Best does not manufacture its supplements, how are the purity and integrity of supplements verified? In addition, how are your prices lower than other brands? Does this mean that quality is being compromised?
A12.	Doctor's Best supplements are manufactured in the US at cGMP (current Good Manufacturing Practice) certified facilities. All of our manufacturers and suppliers go through our vendor qualification program, which includes inspections and testing, before we agree to work with them. Our finished products have also been tested at the raw material level, in process, and as a finished product to ensure safety and quality. We place the highest importance on safety and quality and do not compromise for the sake of a better price point. The price points are lower because of production size and the overall business structure. We also place great importance on making our supplements available and affordable to those who need them most.

Q13.	What is HPLC?
A13.	HPLC stands for "High Performance Liquid Chromatography." This is an analytical lab testing method that is used to quantify the active ingredients. It is considered to be a very sensitive and accurate test. HPLC testing is a tool recognized as a quality benchmark for herbal extracts.

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