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Real Niacin 500mg 120T

Fact Sheet
FAQ's
More Info

Code:

DRB-00242

Size:

120T

MSRP:

$ 24.99

Does Not Contain: milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, salt, or preservatives.

What is it?
Ingredients
Benefits
Safety
Scientific References

11mm Round Tablet

Real Niacin (500mg) 120T

Suitable for vegetarians

Science-based nutrition
Dietary supplement
Promotes cardiovascular health
8-hour extended-release
No/low flush

Real Niacin provides niacin in an 8-hour extended-release form that enables you to enjoy the health benefits of niacin without experiencing the uncomfortable skin flushing that commonly accompanies other forms of niacin.* Niacin comprises approximately 200 coenzymes that play pivotal roles in metabolism and energy production within the body.* Additionally, research suggests that niacin, in combination with a well-balanced diet, may help to maintain healthy cholesterol levels that are already within the normal range.*

Suggested Adult Use: Take one tablet with food, one to two times daily or as directed by your physician.

Supplement Facts
Serving Size: 1 tablet
Serving per container: 120 servings
Amount Per Serving %DV
Niacin 500 mg 2500%
--(as nicotinic acid)
--------------------------------------------------------------------------------------------
† Daily Value not established.

Other Ingredients: Stearic acid, carnauba wax, magnesium stearate (vegetable source), silica.

Caution: Temporary flushing, itching, or warming of the skin may occur upon initial use. If you are under medical supervision, have liver dysfunction, gout, or are pregnant or nursing, consult your physician before taking this product.

Contains nothing other than listed ingredients.

500mg, 120T

Niacin, also known as vitamin B3 or nicotinic acid, supports more than 500 enzymatic reactions that play pivotal roles in metabolism, energy production, and healthy aging. Real Niacin provides a considerable amount of nicotinic acid combined with a proprietary wax-coated technology to yield an 8-hour extended-release tablet that greatly reduces the chance of experiencing the uncomfortable skin flushing that commonly accompanies brands of this vitamin that don’t feature a extended-release mechanism.

Supports cardiovascular health*

Extensive clinical research has shown that niacin as nicotinic acid may promote a favorable balance of blood lipids. The form of niacin typically found in multivitamins and fortified foods is “nicotinamide,” which exhibits vitamin B3 activity but not necessarily the cardiovascular benefits seen in research that examined nicotinic acid. According to a report endorsed by the American Heart Association, nicotinic acid appears capable of modulating blood lipids in part by altering their synthesis and inhibiting the mobilization of free fatty acids.¹Two niacin receptors, HM74 & HM74A, were recently discovered in humans. The HM74A receptors on adipose (fat) cells are believed to be particularly responsible for the helpful blood lipid-altering ability of nicotinic acid.²

Extended-release formula decreases chance of “Skin Flushing”*

Real Niacin provides an 8-hour extended-release tablet that enables more people to access the health-supportive aspects of niacin with less chance of experiencing the uncomfortable skin flushing that commonly accompanies the unspecialized niacin in immediate-release (IR) forms of the vitamin. Release of the eicosanoid prostaglandin D2 from skin cells is believed to be behind the skin flushing that may occur with niacin use. This “prickly heat” phenomenon results in a sensation of warmth, reddening, and/or tingling anywhere from 15 to 120 minutes after consumption of a large dose, often felt on the head, neck, and shoulders for up to an hour. Although flushing is a non-allergic reaction producing no permanent harm to the body, it is the major reason for discontinued use of niacin—thereby preventing many individuals from experiencing the potential benefits of supplementation. When taken as directed, extended-release formulas similar to Real Niacin have been shown to decrease the potential of flushing.^{3, 4}

Supports the maintenance of cognitive function with age*

Diets high in niacin have been associated with healthy cognitive function in the aging mind. This may in part be a result of niacin’s direct role in the regulation of healthy dendritic growth; dendrites are a class of neuronal cells that enable the brain to communicate electric signals to other parts of the brain and the body. Niacin is able to provide potent antioxidant activity to address the accumulation of free radicals in brain mitochondria, the powerhouse organelles within neurons. Niacin is important for many of the complex regulatory pathways utilized by the body to maintain health with age.
The possible associations between niacin intake and the maintenance of healthy cognitive function with age were investigated through the examination of data from the massive Chicago Health and Aging Project (CHAD). The cognitive function in 3718 CHAD participants was assessed by four tests designed to measure mental attributes such as short and long term memory, intellectual ability, and motor control. Among the elderly participants who remained in good health during the 6-year study period, cognitive function was maintained at a 44% greater rate in individuals who had the highest dietary intake of niacin compared to those who consumed the lowest amount of niacin.⁵

Supports healthy metabolism and energy production within the body*

Niacin – in both its nicotinic acid and nicotinamide forms – is well absorbed and can act as a biochemical precursor to nicotinamide adenine dinucleotide (NAD+) and sister coenzyme nicotinamide adenine dinucleotide phosphate (NADP+). The two molecules NAD+ and NADP+ are involved in more than 500 enzymatic reactions and are especially important in metabolism and energy production. All of the human body’s cellular energy is synthesized through mitochondrial oxidative phosphorylation, the citric acid cycle, and cytosolic glycolysis: these pathways all require an adequate supply of NAD+ and NADP+.⁶ Real Niacin supplies nicotinic acid in an extended release form that supports healthy metabolism and energy production throughout the day by helping to provide the body with an abundant pool of NAD+ and NADP+.

Niacin is a safe and effective supplement if taken as directed by the label or your physician.⁴ If you are currently taking statins or other medications, have gout or liver dysfunction, or are otherwise under medical supervision, consult your physician before starting niacin supplementation.

NCEP, Circulation, 2002. 106(25): p. 3143-421.
Vosper, H., Br J Pharmacol, 2009. 158(2):p. 429-41
McKenney, J., Arch Intern Med, 2004. 164(7): p. 697-705.
Guyton, J.R. and H.E. Am J Cardiol, 2007. 99(6A): p. S22-31.
Morris, M.C., et al., J Neurol Neurosurg Psychiatry, 2004. 75(8): p. 1093-9.
Depeint, F., et al., Chem Biol Interact, 2006. 163(1-2): p. 94-112.
Maiese, K., et al., Molecules, 2009. 14(9): p. 3446-85.

FAQ's

Q1.	Can the Real Niacin be broken in half and still maintain the sustained release?
A1.	Yes, the tablets can be broken in half and still maintain sustained release.

Q2.	How long would it take for a TABLET to dissolve?
A2.	FDA Rules & Regulations require tablets to dissolve in 45 minutes or less. However, Doctor’s Best has made the requirement to be that tablets must dissolve in 30 minutes or less. Every lot of every tableted product is tested to verify that it dissolves in under 30 minutes.

Q3.	I am somewhat confused on how to take the DRB products. On many of the labels the Suggested Adult Use will list something along the lines of: Take 2 capsules daily, but it does not state whether they should be taken together or separately. What is the correct usage?
A3.	Unless otherwise specified on the label, the product may be taken together or separately.

Q4.	Is there a limit to how many vitamins can be taken safely in one day?
A4.	While our bodies need vitamins and minerals, like other things, if taken in large amounts they may adversely affect health. Large amounts of anything can be toxic. It is important to follow all label directions and discuss any concerns with your physician.

Q5.	What are the other ingredients and why are they used?
A5.	These are used as flow agents and aid in the production to keep the machinery running smoothly and the capsules filling correctly. Similarly for the croscarmellose sodium, which is cellulose (sourced from the cell walls of green plants), and is used to help disintegrate the tablet in the stomach.

Q6.	It seems that information is now out claiming that magnesium stearate is a form of, or implicated in, trans fat, which everyone now regards as being bad. Why does Doctor’s Best use magnesium stearate in its products?
A6.	Magnesium Stearate is used to work as a lubricant in the formula. Magnesium Stearate is a salt of stearic acid. Stearic acid is a saturated fatty acid. A trans fatty acid (commonly shortened to trans fat) is an unsaturated fatty acid molecule. Stearic acid, being a saturated fatty acid, is not a trans fat. The magnesium stearate used in Doctor’s Best products is vegetable sourced from palm oil.

Q7.	Since Doctor's Best does not manufacture its supplements, how are the purity and integrity of supplements verified? In addition, how are your prices lower than other brands? Does this mean that quality is being compromised?
A7.	Doctor's Best supplements are manufactured in the US at cGMP (current Good Manufacturing Practice) certified facilities. All of our manufacturers and suppliers go through our vendor qualification program, which includes inspections and testing, before we agree to work with them. Our finished products have also been tested at the raw material level, in process, and as a finished product to ensure safety and quality. We place the highest importance on safety and quality and do not compromise for the sake of a better price point. The price points are lower because of production size and the overall business structure. We also place great importance on making our supplements available and affordable to those who need them most.

Q8.	What is HPLC?
A8.	HPLC stands for "High Performance Liquid Chromatography." This is an analytical lab testing method that is used to quantify the active ingredients. It is considered to be a very sensitive and accurate test. HPLC testing is a tool recognized as a quality benchmark for herbal extracts.

Q9.	Does Real Niacin cause hepatitis?
A9.	A number of related compounds are commonly referred to as niacin and/or vitamin B3. These include nicotinic acid, niacinamide, inositol hexaniacinate, a number of different sustained–release (SR) preparations of nicotinic acid, and a prescription only extended–release nicotinic acid (Niaspan). It should also be noted when reading about SR nicotinic acid in other sources, the terms sustained–release, modified–release, and timed–release have been used interchangeably, but may not always refer to identical preparations. The form of niacin used in Doctor’s Best Real Niacin is immediate release (IR) nicotinic acid, which differs from sustained-release (SR) nicotinic acid. Cases of hepatitis associated with use of high doses of IR nicotinic acid (>3 grams per day) have been reported. Exactly how common this is is not well defined in the medical literature, but it appears to be very rare. Niacin–induced hepatitis usually occurs between 1–18 months after starting use. To

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