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Fact Sheet
FAQ's
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Code:

DRB-00275

Size:

120S/G

MSRP:

$ 179.99

Does Not Contain: milk, egg, wheat, gluten, corn, sugar, sweeteners, starch, salt, or preservatives.

What is it?
Ingredients
Benefits
Safety
Scientific References

20 Oblong Softgel

Best Ubiquinol featuring Kaneka QH™ (200mg) 120 Softgels

Science-based nutrition
Dietary supplement
Mitochondrial support to enhance cellular energy production*
Supports healthy heart function*
Powerful antioxidant action*

Best Ubiquinol featuring Kaneka's QH™ contains the reduced form of coenzyme Q10. Both ubiquinol (CoQ10-H2) and ubiquinone (CoQ10) are metabolically active, and are interchangeable in the body according to needs. Each form has unique roles in cells including antioxidant actions, supporting healthy heart functioning and enhancing energy production*. Oral ubiquinol may offer improved bioavailability in individuals who have difficulty achieving high levels of this nutrient, such as aging adults or those concerned with nutrient absorption*.

Suggested Adult Use: Take 1 softgel daily with food, or as directed by a nutritionally informed physician.

Supplement Facts
Serving Size: 1 capsule
Servings per container: 120 servings
Amount Per Serving %DV
Ubiquinol (Kaneka QH™ reduced form of CoQ10) 200mg †
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† Daily Value not established

Other Ingredients: Extra virgin olive oil, medium-chain triglycerides, beeswax, rosemary leaf extract, vitamin E (as d-alpha tocopherol), soy lecithin, gelatin (capsule), glycerin, annatto (color).

Contains nothing other than listed ingredients.

200mg, 120S/G

Best Ubiquinol featuring Kaneka QH™ contains the reduced form of coenzyme Q10. Both ubiquinol (CoQ10-H2) and ubiquinone (CoQ10) are metabolically active, and are found naturally in the body and in food sources. The two forms are interchangeable, as the body appears to keep the reduced and oxidized forms in the “total pool” at a constant ratio.^1-3 Each form has unique roles to play in cells including antioxidant actions and enhancement of energy production in the mitochondria. The commonly available supplement form of coenzyme Q10 has been the oxidized form (ubiquinone), as until recently the reduced form was difficult to manufacture due to its rapid oxidation in the air. New technology has allowed for the manufacturing of stable coenzyme Q10 in the reduced form.4 The results from an animal study that compared the absorption of the two different forms, as well as a human study showing significant absorption of ubiquinol, together suggest that taking ubiquinol orally may offer improved bioavailability in individuals who have difficulty achieving high levels of this nutrient, such as aging adults or those concerned with nutrient absorption.⁴Comparison studies of the two forms are now necessary in humans to confirm this idea, as well as determine the specific circumstances under which ubiquinol may be more beneficial.

Ubiquinol has powerful antioxidant actions in target cells

Although ubiquinone (oxidized coenzyme Q10) and ubiquinol (reduced coenzyme Q10) are kept at a constant ratio within the body, the majority of the total coenzyme Q10 pool is made up of ubiquinol. In fact, when ubiquinone is taken orally, much of it appears to be rapidly converted into ubiquinol.^{1, 4} Ubiquinol functions as a potent antioxidant in humans, including in the bloodstream.^{1, 4, 5} The coenzyme Q10 molecule can be found in all membranes throughout cells.⁶It appears to works in conjunction with both vitamin E and vitamin C to provide antioxidant actions throughout the body.⁷

Coenzyme Q10 supports mitochondria to enhance cellular energy production*

Coenzyme Q10, with its widespread distribution throughout the body, plays a crucial role in mitochondrial physiology as a critical member of the electron transport chain. This transport chain, which is part of cellular respiration, leads to the formation of adenosine triphosphate (ATP), our body’s primary energy source. Levels of this key nutrient may decline as a healthy person ages.^{7, 8} Animal studies have found that supplementation can restore normal levels in certain tissues,6 and human studies suggest that supplementing with this enzyme may have increased benefits when a person has depleted levels.⁷

Coenzyme Q10 supports healthy heart functioning*

Concentrations of coenzyme Q10 are understandably high in the heart as these muscle cells require high levels of energy to constantly function optimally. A number of studies (both animal and human) strongly suggest that coenzyme Q10 supplementation is supportive for healthy heart functioning and for maintaining cardiovascular system health.^{7, 9}

Ubiquinol has been studied for safety and bioavailability in humans*

A recently published single-blind placebo-controlled study in healthy subjects found no safety concerns in people who took Kaneka’s QH ubiquinol supplement orally at doses of up to 300 milligrams daily for up to four weeks.⁴Single oral doses of either 150 milligrams or 300 milligrams were given to fifteen healthy men and women, and standard laboratory testing (including hematology, blood chemistry, and urinalysis) as well as physical examination and electrocariography (EKG) results showed no clinically significant changes when tested two days after supplementation as compared to before the taking the supplement. In addition to the single dose study, 80 healthy volunteers were given either placebo, 90, 150 or 300 milligrams of ubiquinol each day for four weeks, and again no clinically significant differences were seen in any of the testing parameters after two and four weeks of supplementation, nor were there differences two weeks after discontinuation of the supplement. By monitoring levels in the blood, the authors found that ubiquinol was well absorbed.⁴

Studies in several animals also reveal no concern of toxicity in doses of ubiquinol up to 200 milligrams per kilogram of body weight for up to thirteen weeks.⁴ When compared to humans, this dose level is enormously higher than the recommended doses. Supplementation with ubiquinol appeared to be safe at even higher levels (up to 600 milligrams per kilogram body weight) in a study using a different animal. In vitro assays additionally found no safety concerns for the use of ubiquinol, as it was found to be non-mutagenic and did not cause damage to chromosomes in cells.

Mohr D, Bowry VW, Stocker R. Biochim Biophys Acta 1992;1126:247-54.
Weber C, Jakobsen TS, Mortensen SA, others. Mol Aspects Med 1994;15 Suppl:s97-102.
Okamoto T, Matsuya T, Fukunaga Y, others. Int J Vitam Nutr Res 1989;59:288-92.
Hosoe K, Kitano M, Kishida H, others. Regul Toxicol Pharmacol 2007;47:19-28.
Stocker R, Bowry VW, Frei B. Proc Natl Acad Sci U S A 1991;88:1646-50.
Crane FL. J Am Coll Nutr 2001;20:591-8.
Jones K, Hughes K, Mischley L, McKenna DJ. Altern Ther Health Med 2004;10:22-30; quiz 31.
Schulz C, Obermuller-Jevic UC, Hasselwander O, others. Int J Food Sci Nutr 2006;57:546-55.
Altern Med Rev 2007;12:159-68.

FAQ's

Q1.	How much KanekaQH™ (ubiquinol) should I take?
A1.	The recommended dose of KanekaQH™ varies based on each individual’s needs. However, those who are older or suspect they have decreased CoQ10 may want to start supplementing with 200-300 mg of KanekaQH™ per day. Studies show that the CoQ10 plasma levels plateau at about two weeks at this dose. Then, 100 mg per day is a good maintenance dose.

Q2.	Why should I be concerned about declining ubiquinol levels?
A2.	Declines in ubiquinol result in less cellular energy and diminished protection against oxidative stress, which produces free radicals and can damage the body’s cells, including proteins, lipids and DNA. Ubiquinol provides a strong first-stage defense against this cellular oxidative damage and needs to be replenished to maintain optimum health. An increasing number of scientific reports indicate that dramatic decreases in ubiquinone levels and increased oxidative stress are associated with the aging process.

Q3.	Why does supplementing with ubiquinol become more important as I age?
A3.	As a healthy 20-year-old, you readily produce all of the CoQ10 you can use and efficiently convert it into ubiquinol. In fact, the predominant form of CoQ10 in the plasma and tissues of a healthy individual is the reduced ubiquinol form. However, age and other factors can hinder the body’s ability to produce and metabolize CoQ10. Some reasons for this include increased metabolic demand, insufficient dietary intake, oxidative stress, or any combination of these things. Some reports say this decline becomes apparent around 40 years old, although it can begin as early as 20 in some cases. As the body’s ability to produce and reduce CoQ10 begins, supplementation with CoQ10 and/or ubiquinol becomes increasingly important to maintaining good health*.

Q4.	How do I know which form of CoQ10 is right for me?
A4.	For young, healthy individuals, KanekaQ10™ should usually be sufficient for supplementation needs. Healthy adults in their 20s and 30s can easily metabolize CoQ10 and convert it into ubiquinol; thus, supplementing with CoQ10 likely will be the most efficient way to raise CoQ10 levels. For individuals who are 40+, KanekaQHä (ubiquinol) is likely more beneficial since the body’s ability to produce CoQ10 and convert it into ubiquinol is diminished. Optimal ubiquinol levels are important to those looking to support cardiovascular, neurological and liver health. Because KanekaQH™ is pre-converted, it is ready for immediate use by the body, making it ideal for those unable to efficiently reduce CoQ10 in the body

Q5.	How long will I have to take Kaneka QH™ before feeling the benefits?
A5.	Ubiquinol is not a quick fix for those looking for increased energy. Unlike caffeine or sugar which boost energy levels quickly and can cause a “crash” later, ubiquinol offers sustained natural energy*. Although each individual is different, it generally takes two to three weeks to restore optimal CoQ10 levels in blood plasma and tissues, most people will begin feeling the effects as their individual plasma levels start to increase, generally around the fifth day.

Q6.	Does Doctor's Best CoQ10 have propyl glycol in it or is it ever around it?
A6.	No and no.

Q7.	What is the source of the gelatin found in the softgel found in several of the DRB products?
A7.	The source of the gelatin softgels is beef.

Q8.	I am somewhat confused on how to take the DRB products. On many of the labels the Suggested Adult Use will list something along the lines of: Take 2 capsules daily, but it does not state whether they should be taken together or separately. What is the correct usage?
A8.	Unless otherwise specified on the label, the product may be taken together or separately.

Q9.	Is there a limit to how many vitamins can be taken safely in one day?
A9.	While our bodies need vitamins and minerals, like other things, if taken in large amounts they may adversely affect health. Large amounts of anything can be toxic. It is important to follow all label directions and discuss any concerns with your physician.

Q10.	What are the other ingredients and why are they used?
A10.	These are used as flow agents and aid in the production to keep the machinery running smoothly and the capsules filling correctly. Similarly for the croscarmellose sodium, which is cellulose (sourced from the cell walls of green plants), and is used to help disintegrate the tablet in the stomach.

Q11.	Why do you use soy lecithin in some of your products?
A11.	Soy lecithin is used as an emulsifier/stabilizer.

Q12.	Since Doctor's Best does not manufacture its supplements, how are the purity and integrity of supplements verified? In addition, how are your prices lower than other brands? Does this mean that quality is being compromised?
A12.	Doctor's Best supplements are manufactured in the US at cGMP (current Good Manufacturing Practice) certified facilities. All of our manufacturers and suppliers go through our vendor qualification program, which includes inspections and testing, before we agree to work with them. Our finished products have also been tested at the raw material level, in process, and as a finished product to ensure safety and quality. We place the highest importance on safety and quality and do not compromise for the sake of a better price point. The price points are lower because of production size and the overall business structure. We also place great importance on making our supplements available and affordable to those who need them most.

Q13.	What is HPLC?
A13.	HPLC stands for "High Performance Liquid Chromatography." This is an analytical lab testing method that is used to quantify the active ingredients. It is considered to be a very sensitive and accurate test. HPLC testing is a tool recognized as a quality benchmark for herbal extracts.

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