Best Fisetin featuring Cognisetin 30VC

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Code:

DRB-00227

Size:

30 VC

MSRP:

$ 21.99

Does Not Contain: milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, or preservatives.

What is it?
Ingredients
Benefits
Safety
Scientific References

Capsule 1

Best Fisetin featuring Cognisetin™ 30VC

Suitable for vegetarians

Science-based nutrition
Dietary supplement
Advancing the frontiers of brain health enhancement*
Flavonol antioxidant support for healthy aging*

Best Fisetin featuring Cognisetin™ offers a naturally sourced flavonol that displays many effects on brain cells and cognitive function pathways in preclinical research. Fisetin is a bioflavonoid antioxidant that can help maintain glutathione levels and mitochondrial function in the presence of oxidative stress. It has potential to cross the blood brain barrier, which may help maintain neuronal function even in the face of factors that contribute to normal age-associated decline in brain function. Other than strawberries, fisetin is scarce in fruits and vegetables compared to other flavonoids, making Best Fisetin featuring Cognisetin™ a most reliable source of this powerful antioxidant and potential nootropic.

Suggested Adult Use: Take 1 capsule daily, with water.

Supplement Facts
Serving size: 1 capsules
Servings Per Container: 30 servings
Amount Per Serving %DV
Fisetin (as Cognisetin™) 100mg †
(from Rhus succedanea) (stem)
----------------------------------------------------------------------------------------------
† Daily Value not established.

Other Ingredients: Modified cellulose (vegetarian capsule), microcrystalline cellulose.

Contains nothing other than listed ingredients.

100mg, 60VC

Doctor's Best Supplements - Ingredients - Best Fisetin featuring Cognisetin 30VC

Best Fisetin featuring Cognisetin™ provides the flavonol fisetin, a bioflavonoid produced in plants to protect them from oxidative damage.¹ Although fisetin is found in fruits and vegetables such as apple, cucumber, grape, kiwi, onion, and persimmon, it is only abundantly found in strawberry.² Cognisetin™ is derived from the Japanese Wax Tree, a much richer source of fisetin that has been used for decades.

While results from various modes of research have been strong and convincing, clinical studies on fisetin have not yet been undertaken. Because of this, the dose of Best Fisetin featuring Cognisetin™ is based upon an FDA model converting the mice dose of fisetin (in research showing long-term memory benefits) to an optimal, safe, human equivalent.

Every batch of Cognisetin™ undergoes NutriPrint®, which includes qualitative identity testing by Fourier Transform Near-Infrared Spectrometer (a method that produces extremely accurate measurements) and third-party certification of analysis by independent laboratories using validated methods of analysis for the active ingredient, microbes, heavy metals, and pesticide testing.

Flavonol antioxidant support for healthy aging*

Fisetin can support the body’s antioxidant pool both through direct radical scavenging activity and through enhancement of glutathione (GSH) levels. In vitro research suggests that fisetin can support the body’s glutathione (a very active antioxidant found naturally in the human body) by supplying cystine—a building block of GSH—to cells, or by enhancing GSH synthesis. Fisetin may help to regulate production of many proteins involved in guarding cells from oxidative stress and in maintaining redox homeostasis (the balance between rates of free radical production and rates of removal by various antioxidants).³

In laboratory research on the effects of many flavonoids on neurons, only fisetin and quercetin were able to maintain glutathione levels in the face of oxidative stress.⁴ Researchers have also demonstrated the ability of fisetin to enhance or maintain mitochondrial ATP (energy) levels in nerve cells during conditions of oxidative stress induced by the toxin iodoacetic acid.⁵ Since the mitochondria are both a target for damage by oxidants and a primary source of oxidants generated inside cells, changes in mitochondrial function are thought to be associated with aging; therefore, fisetin is believed to support neurons and aging of the brain by supporting healthy mitochondrial function.³ In addition to fisetin helping to maintain GSH levels while nerve cells are exposed to the toxic insults of everyday life, fisetin has been shown in vitro to promote detoxification aspects of the cellular defense system against ongoing oxidative stress.⁵

Supports the aging brain.*

Normal aging is characterized by a decline of brain motor and cognitive functions, affecting learning, memory, and coordination.³ Memory deficits associated with normal aging affect the quality of life. Originally valued chiefly for their antioxidant, radical-scavenging activities, flavonoids are now known to have a wide range of properties that support brain function with age. Scientists debate whether flavonoids can reach high enough levels in the brain to affect neuronal function. This is because the blood-brain barrier, which consists of specialized brain capillaries and astrocytes (cells that provide support for neurons), prevents the passage of many materials from the blood to the brain. Using an in vitro model (for practical reasons) to assess fisetin in its capacity to cross the blood-brain barrier, fisetin was found to have high brain uptake potential.³

In a combination study that used both in vivo and in vitro methods, results illustrated that fisetin can facilitate the development of long-term memory by activating signaling pathways in the rat hippocampus (a part of the mammalian brain’s limbic system).⁶ The researchers tested the in vitro findings (biochemical effects seen in the rat hippocampus) by using mice in an object-recognition task very effective for measuring functions such as a critical step in the signaling cascade (the chain transmission of cellular signals) that leads to structural changes important for the development of long-term memory.

The Morris water maze (MWM) is a rodent learning test that is correlated with synaptic plasticity, or brain cell connections, in the hippocampus. Before fisetin alone was researched for its nootropic (cognitive enhancement) potential, researchers found that strawberry extract enhanced the performance of rats in MWM tests (strawberries are the best food source of fisetin).⁷ Later, researchers began to use the MWM test with fisetin as the test compound; they found that it significantly improved the memory of older mice (compared to control mice not fed fisetin).³

AREAS FOR FURTHER RESEARCH

In rat glial cells (cells providing support for neurons), the observed effects of fisetin suggested influence on the regulation of cellular concentrations of catecholamines and 5-HT (monoamine neurotransmitters) in the brain. The latest research suggests that fisetin can influence mood by altering these neurotransmitters. In a paper published in 2012, the authors reported fisetin-induced benefits to mood in mice observed in two classical models of despair tasks; pharmacological, biochemical, and neurochemical paradigms were used to confirm that monoamine neurotransmitters like 5-HT were indeed affected by fisetin.⁸ Increasingly in the 21^st century, many scientists are also backing the theory of oxidative stress contributing to mood states, which further adds credence to fisetin holding potential to contribute to a healthy mood.

In a completely different line of new research, fisetin was found to be able to beneficially influence protein glycation in mice.⁹ Protein glycation can result in the formation of advanced glycation end-products (AGEs) by a complex series of reactions between reducing sugars and amino acids on proteins. While this reaction is best known for its effects in the culinary world, it also takes place within the body—and it accelerates as we age; while AGEs are considered favorable in the culinary world, they are considered unfavorable in the terms of health. Another compelling finding of the study was that fisetin reduced nervous tension among the mice in the study population. In yet another leading edge study, fisetin was found to support airway health in mice.² These studies have provided the incentive for fisetin clinical trials to be designed and carried out, with the goal of determining to what degree human health may be enhanced by this powerful flavonol.

Does Not Contain: milk, egg, wheat, gluten, corn, sugar, sweeteners, starch, or preservatives.

1. Inkielewicz-Stepniak I, Radomski MW, et al. Food Chem Toxicol. 2012; 50: 583-9.

2. Goh FY, Upton N, et al. Eur J Pharmacol. 2012; 679: 109-16.

3. Maher P. Genes Nutr. 2009.

4. Ishige K, Schubert D, et al. Free Radic Biol Med. 2001; 30: 433-446.

5. Maher P, Salgado KF, et al. Brain Res. 2007; 1173: 117-25.

6. Maher P, Akaishi T, et al. Proc Natl Acad Sci U S A. 2006; 103: 16568-73.

7. Joseph JA, Shukitt-Hale B, et al. J Neurosci. 1999; 19: 8114-21.

8. Zhen L, Zhu J, et al. Behav Brain Res. 2012; 228: 359-66.

9. Maher P, Dargusch R, et al. PLoS One. 2011; 6: e21226.

FAQ's

Q1.	What is modified cellulose and is it safe?
A1.	The cellulose is derived from alpha cellulose from softwood pulp. This softwood pulp may be derived from hemlock, spruce or other soft woods. It is made by cooking raw plant fiber in an aqueous solution to separate the cellulose, and then purified. It then goes through extra processing to further break down the fiber. The finished product contains no residual solvents. Excipients are needed to make the materials flow into the capsule and are extremely minute in amounts and are safe.

Q2.	I am somewhat confused on how to take the DRB products. On many of the labels the Suggested Adult Use will list something along the lines of: Take 2 capsules daily, but it does not state whether they should be taken together or separately. What is the correct usage?
A2.	Unless otherwise specified on the label, the product may be taken together or separately.

Q3.	Is there a limit to how many vitamins can be taken safely in one day?
A3.	While our bodies need vitamins and minerals, like other things, if taken in large amounts they may adversely affect health. Large amounts of anything can be toxic. It is important to follow all label directions and discuss any concerns with your physician.

Q4.	What are the other ingredients and why are they used?
A4.	These are used as flow agents and aid in the production to keep the machinery running smoothly and the capsules filling correctly. Similarly for the croscarmellose sodium, which is cellulose (sourced from the cell walls of green plants), and is used to help disintegrate the tablet in the stomach.

Q5.	What is cellulose and modified cellulose produced from?
A5.	Southern pine and spruce.

Q6.	What is the source of the cellulose found in the some of the Doctor’s Best products?
A6.	The cellulose is made from alpha cellulose from softwood pulp. This softwood pulp may be derived from hemlock, Spruce or other soft woods.

Q7.	Since Doctor's Best does not manufacture its supplements, how are the purity and integrity of supplements verified? In addition, how are your prices lower than other brands? Does this mean that quality is being compromised?
A7.	Doctor's Best supplements are manufactured in the US at cGMP (current Good Manufacturing Practice) certified facilities. All of our manufacturers and suppliers go through our vendor qualification program, which includes inspections and testing, before we agree to work with them. Our finished products have also been tested at the raw material level, in process, and as a finished product to ensure safety and quality. We place the highest importance on safety and quality and do not compromise for the sake of a better price point. The price points are lower because of production size and the overall business structure. We also place great importance on making our supplements available and affordable to those who need them most.

Q8.	What is HPLC?
A8.	HPLC stands for "High Performance Liquid Chromatography." This is an analytical lab testing method that is used to quantify the active ingredients. It is considered to be a very sensitive and accurate test. HPLC testing is a tool recognized as a quality benchmark for herbal extracts.

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