Best Noni Concentrate is a whole-food supplement containing pure non-GMO Noni fruit powder (Morinda citrifolia). Recognized as a valuable food by the U.S. government for nearly 60 years, Noni fruit contains vitamin C, enzymes and other beneficial substances. Noni fruit has a long history of traditional use in South Pacific island societies as a versatile folk remedy.
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Suggested Adult Use: Take 2 capsules three times daily, with or without food.
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Supplement Facts Serving Size: 2 Capsules Serving per container: 75 servings Amount Per Serving        %DV Organic Noni (fruit) (Morinda citrifolia)                      1300 mg            †- Using 100% Organic material ---------------------------------------------------------------------------------- †Daily Values not established.
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Other ingredients: Non-organic vegetable (polysaccharide) capsule.
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Certified Organic by Organic Certifiers
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Contains nothing other than listed ingredients.
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650mg, 150VC
Best Noni contains pure dried Morinda citrifolia fruit, commonly known as Noni. The Morinda citrifolia plant has a long history of traditional use in Southeast Asia and the South Pacific for a spectrum of healthful purposes. As ancestors of Polynesians migrated from Southeast Asia two millennia ago, they presumably brought with them plants that were valued for their nutritional content and other health-promoting qualities. Scholars believe that noni was very prominent among the plants that were brought to Polynesia to help the migrants maintain health.1 Polynesian mythology relates a number of stories where noni is central to the hero averting famine. In more recent times, noni fruit was recognized as a food source in a field manual issued to U.S. soldiers during World War II.2 The fruit is known as a good source of potassium and other minerals, and its nutritional profile includes several fatty acid glycosides that appear to be unique to noni when the fruit is ripe.3
Since it is today found in most tropical regions, noni also goes by many other names, including Indian Mulberry, Hai Ba Ji, Cheese Fruit, and Nhau.4 While some ethnobotanical reports document its use as a food, noni was (and continues to be) commonly used in many cultures to support diverse areas of wellness such as joint health, immune function, and enhancement of carbohydrate metabolism. In Malaysia, where noni goes by the name Mengkudu, the raw fruit is customarily eaten to purify the blood.5
Multifaceted Antioxidant Support* Helps Maintain Healthy Cellular Lifecycles and Growth*
Abundant in Phytochemicals As of 2010, over 100 bioactive compounds have been discovered in noni fruit. Among the phytochemical classes are flavonoids (including rutin & quercetin), coumarins (scopoletin), fatty acids, iridoids, lignans, phytosterols ( -sitosterol), polysaccharides, and terpenoids.3 Researchers speculate that this diversity of compounds—in addition to possible synergistic actions between them—could explain the equally diverse traditional uses for noni over for centuries.4 In vitro examination of noni fruit extract revealed antioxidant activity as potent as that of vitamin E.6
Four saccharide fatty acid esters from noni fruit, including one that was newly discovered, displayed anti-inflammatory activity in mice that was even more potent than the action of quercetin, which is another natural compound found in noni and one that is revered for its antioxidant and inhibitory activity.7 Another study that discovered two new lignans in noni fruit also found that these lignans—in addition to several other compounds—inhibited inflammatory enzymes found in humans, in vitro.8 In yet another study that investigated inflammation and immune response, noni fruit puree was used experimentally both in mice and in human monocyte (white blood cell) culture.9 The results were impressive in both respects, demonstrating inhibition of MMP-9 (a marker of inflammation) in the cell cultures and inhibition of inflammatory enzymes in the mice.
Iridoids: Not found in your average fruit Iridoids are a class of plant compounds that have demonstrated a wide range of bioactivity, including physiological actions that have potential to enhance health in humans.10 While most fruit abounds with various flavonoids, this is not the case with iridoids. Noni, on the other hand, boasts a higher content of iridoids than flavonoids—including an unusual and active iridoid named citrifolnin A that shows remarkable activity in vitro.11, 12 The major iridoids in noni fruit, as determined by HPLC analysis done in 2010, are deacetylasperulosidic acid (DDA) and asperulosidic acid (AA).13 Having worked extensively with noni, the researchers making this discovery proposed that the DDA & AA may be contributors to many of noni’s wide spectrum of health-promoting effects. Animal studies have illustrated the utility of asperulosidic acid in promoting the maintenance of healthy cell function in the face of extreme adversity (toxic insults).10 Additionally, deacetylasperulosidic acid has been found in vitro to inhibit lipid oxidation at a strikingly high level for a natural compound.14
Leading Edge Noni Findings In a 2010 study of rats put on a high-fat diet, some of the rats were also fed noni fruit extract. The fruit extract helped a subgroup of rats in the study maintain a significantly more preferable level of blood lipids than those not receiving the noni extract.15 The researchers believe that Morinda citrifolia achieves these results in part through the inhibition of HMG Co-A, but that other mechanisms—such as the flavonoid content of noni—are probably also contributing to the inhibition of lipid biosynthesis. Furthermore, they conclude that the high antioxidant content of noni can battle the oxidative stress caused by the amount of lipid biosynthesis that does occur. The results from this animal study have further paved the way for clinical investigations to be carried out in order to clearly define the potential cardiovascular benefits of noni extract.
Noni: Then and Now The tireless pursuit of uncovering scientific knowledge to help us understand the actions of noni on human health is ongoing, in part due to an interest in finding mechanisms to explain why the traditional use of noni was, and continues to be, so prominent. Additionally, exciting new areas of interest currently undergoing clinical investigation include cognitive function and athletic endurance.
Numerous toxicity tests and a clinical study have been performed to ensure the safety of noni juice.16, 17 More recently, an HPLC lab analysis of noni fruit puree found it to be void of potentially genotoxic anthraquinones, alleviating any safety concerns about these compounds that are found in the noni root.18 The European Commission (EC) approved noni fruit juice as a novel food in 2003.9 This action gives much credence to the safety of noni, as EC regulations are strict and require scientific evidence showing that novel foods do not present a danger for the consumer.
Wang, M.Y., et al., Acta Pharmacol Sin, 2002. 23(12): p. 1127-41.
Merrill, E., Technical manual. Emergency food plants and poisonous plants of the islands of the Pacific, W. Department, Editor. 1943, US Government Printing Office: Washington DC.
Potterat, O. and M. Hamburger, Planta Med, 2007. 73(3): p. 191-9.
Deng, S., B. West, and C. Jensen, Food Chem, 2010. 122(2010): p. 267-270.
Zakaria, M.b. and M.A. Mohd, 1994, Penerbit Fajar Bakti Sdn. Bhd.: Kuala Lumpur. p. 95.
Zin, Z., A. Abdul-Hamid, and A. Osman, Food Chem, 2002. 78(2002): p. 227-231.
Akihisa, T., et al., J Nat Prod, 2007. 70(5): p. 754-7.
Deng, S., et al., J Nat Prod, 2007. 70(5): p. 859-62.
Basar, S., et al., Phytother Res, 2010. 24(1): p. 38-42.
Tundis, R., et al., Mini Rev Med Chem, 2008. 8(4): p. 399-420.
Dinda, B., S. Debnath, and Y. Chem Pharm Bull (Tokyo), 2007. 55(5): p. 689-728.
Deng, S., Journal of Medicinal Foods Plants, 2010. 2(1): p. 6-9.
Deng, S., et al., Phytochem Anal, 2010.
Kim, D.H., et al., Arch Pharm Res, 2005. 28(10): p. 1156-60.
Mandukhail, S.U., N. Aziz, and A.H. Gilani, Lipids Health Dis, 2010. 9(1): p. 88.
West, B., et al., J Food Sci, 2006. 71(8): p. R100-R106.
Is the Noni in the Best Noni heated during production and if so, at what temperature?
A1.
The Noni is not heated during production. It is sun dried and in its final stage, it is in a green house in ambient temperatures. The drying stage is all natural.
Q2.
What is modified cellulose and is it safe?
A2.
The cellulose is derived from alpha cellulose from softwood pulp. This softwood pulp may be derived from hemlock, spruce or other soft woods. It is made by cooking raw plant fiber in an aqueous solution to separate the cellulose, and then purified. It then goes through extra processing to further break down the fiber. The finished product contains no residual solvents. Excipients are needed to make the materials flow into the capsule and are extremely minute in amounts and are safe.
Q3.
I am somewhat confused on how to take the DRB products. On many of the labels the Suggested Adult Use will list something along the lines of: Take 2 capsules daily, but it does not state whether they should be taken together or separately. What is the correct usage?
A3.
Unless otherwise specified on the label, the product may be taken together or separately.
Q4.
Is there a limit to how many vitamins can be taken safely in one day?
A4.
While our bodies need vitamins and minerals, like other things, if taken in large amounts they may adversely affect health. Large amounts of anything can be toxic. It is important to follow all label directions and discuss any concerns with your physician.
Q5.
What are the other ingredients and why are they used?
A5.
These are used as flow agents and aid in the production to keep the machinery running smoothly and the capsules filling correctly. Similarly for the croscarmellose sodium, which is cellulose (sourced from the cell walls of green plants), and is used to help disintegrate the tablet in the stomach.
Q6.
Since Doctor's Best does not manufacture its supplements, how are the purity and integrity of supplements verified? In addition, how are your prices lower than other brands? Does this mean that quality is being compromised?
A6.
Doctor's Best supplements are manufactured in the US at cGMP (current Good Manufacturing Practice) certified facilities. All of our manufacturers and suppliers go through our vendor qualification program, which includes inspections and testing, before we agree to work with them. Our finished products have also been tested at the raw material level, in process, and as a finished product to ensure safety and quality. We place the highest importance on safety and quality and do not compromise for the sake of a better price point. The price points are lower because of production size and the overall business structure. We also place great importance on making our supplements available and affordable to those who need them most.
Q7.
What is HPLC?
A7.
HPLC stands for "High Performance Liquid Chromatography." This is an analytical lab testing method that is used to quantify the active ingredients. It is considered to be a very sensitive and accurate test. HPLC testing is a tool recognized as a quality benchmark for herbal extracts.
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