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Best Serrapeptase 270VC

Fact Sheet
FAQ's
More Info

Code:

DRB-00190

Size:

270 VC

MSRP:

$ 69.99

Does Not Contain: milk, egg, wheat, gluten, soy, sugar, sweeteners, starch, salt, or preservatives.

What is it?
Ingredients
Benefits
Safety
Scientific References

Size 0 Capsule

Best Serrapeptase 270 Veggie Caps

Suitable for Vegetarians

Science-based nutrition
Dietary supplement

Serrapeptase is a proteolytic enzyme isolated from the non-pathogenic bacteria Serratia species found in the digestive tract of the Japanese silkworm. The enzyme is used by the worms to digest their cocoons. Serrapeptase has been used as a nutritional supplement in Europe and Asia for nearly three decades. Each vegetarian capsule of Best Serrapeptase contains enteric-coated pure serrapeptase designed for optimal absorption in the intestinal tract.

Suggested Adult Use: Take 1 to 3 capsules daily, away from food.

Supplement Facts
Serving size: 1 Capsule
Servings Per Container: 270 servings
Amount Per Serving % DV
Serrapeptase 40,000 Units †
- (enteric coated capsule)
---------------------------------------------------------------------------------------
† Daily Value not established.

Other ingredients: Cellulose, modified cellulose (vegetarian capsule), enteric coating (HPMCP)

Contains nothing other than listed ingredients.

270VC

Serrapeptase is a proteolytic enzyme first isolated from the non-pathogenic Serratia bacteria species strain E15 by Japanese researchers in 1966.¹ Proteolytic enzymes, as the term implies, break down proteins. Serratia E15 was discovered in the Japanese silkworm, which harnesses serrapeptase enzyme activity to break down its cocoon walls.^1,2 Each enteric-coated vegetarian capsule of Best Serrapeptase and Best High Potency Serrapeptase contains pure serrapeptase designed for optimal absorption in the intestinal tract.

Note: Best Serrapeptase is quantified in “Serratiopeptidase units,” which refers to the enzyme activity level. Enzymes like Serrapeptase are not measured in milligrams (mg), but in an unassociated measure of units. Best Serrapeptase has 40,000 Serratiopeptidase units per capsule, which is considered a very high amount of activity. Since Best High Potency Serrapeptase contains a tremendous 120,000 units, suggested use is only 1 capsule per day.

Promotes & Maintains Healthy Sinus and Airway Function*

Supports Healthy Immune Response*

The mucous membranes are a thin tissue layer or epithelium that lines the body’s hollow structures (cavities) opening to the exterior, such as the upper respiratory system. They secrete a slightly viscous fluid called mucus, which is actually a complex viscoelastic gel that lubricates and moistens the cavity surfaces. As a part of normal, healthy physiology, mucus is the first line of defense in the nose and lungs to trap and filter inhaled dust, pollutants, and other potentially damaging agents. Proteolytic enzymes such as serrapeptase can break down inappropriate protein complexes in the mucus, thereby favorably influencing its properties and helping to support the healthy balance between adequate mucous viscosity/elasticity and airway comfort levels associated with the mucous membranes of the respiratory system.^3-5

Research with serrapeptase for maintenance of healthy sinus function began decades ago in Japan. Studies thus far indicate that serrapeptase is a safe and useful supplement to promote favorable viscosity of nasal and bronchial mucus. Two of the earliest human trials found that serrapeptase had favorable effects on upper airway viscosity.^3,4 In these assessments, mucus was collected from participants after a 4-week supplementation period and evaluated using an rheometer to determine its viscoelastic properties. The enzyme’s action most likely involves the breakdown of mucus protein structures, consequently allowing the cilia (microscopic hairlike projections in the mucosal epithelium of the upper respiratory tract) to helpfully transport mucus in the airway.

Serrapeptase can also significantly affect sputum viscoelasticity.^5,6 In an investigation of forty individuals who were randomly assigned to one of five groups, six participants were given serrapeptase for one week. Sputum viscoelasticity was analyzed using a rheometer and researchers concluded that serrapeptase altered the “relaxation behavior” of sputum—meaning that serrapeptase helped support airway clearance.⁵

In a subsequent larger double blind trial, 193 participants were randomized into two groups and were instructed to take either serrapeptase or placebo 3 times daily after meals for one week.⁷ After 4 days and at the end of the 7–8 day period, mucus secretion, airway freedom, and measures of immune response were significantly favorable in the serrapeptase group compared with the placebo group. A recent study in which the immune system of rats was challenged further confirms human data that serrapeptase can be used for supporting the immune system.⁸

In a controlled and randomized open-label study of 29 subjects, researchers again observed the effects of serrapeptase supplementation on sputum. After 4 weeks, subjects taking serrapeptase had significantly less morning sputum with favorable viscoelasticity; furthermore, the serrapeptase group had fewer neutrophils in their sputum, signifying a more balanced immune response to maintain airway health.⁹

Potency

Doctor’s Best discloses the potency details of Serrapeptase so you know exactly what you're getting. Enzyme strength is measured in terms of activity rather than weight, because an enzyme can be present but unless it is functional it will not be useful. Therefore, an enzyme product label should list the enzyme’s functional activity, and this usually will come from a laboratory measure as standard activity units. For serrapeptase the best standard measure is “Serratiopeptidase Units” or SPU.

To meet your individual needs, there are two levels of potency to choose from with Best Serrapeptase enteric-coated vegetarian capsules—either 40,000 or 120,000 SPU.

Best Serrapeptase has 40,000 SPU per capsule, which is considered a very high activity. Since Best High Potency Serrapeptase contains a tremendous 120,000 units, its suggested use is only 1 capsule per day.

1. Miyata K, Maejima K, Tomoda K, Isono M. Agr Biol Chem 1970;34:310-318.

2. Mecikoglu M, Saygi B, Yildirim Y, others. J Bone Joint Surg Am 2006;88:1208-14.

3. Majima Y, Inagaki M, Hirata K, others. Arch Otorhinolaryngol 1988;244:355-9.

4. Majima Y, Hirata K, Takeuchi K, others. Am Rev Respir Dis 1990;141:79-83.

5. Shimura S, Okubo T, Maeda S, others. Biorheology 1983;20:677-83.

6. Kase Y, Seo H, Oyama Y, others. Arzneimittelforschung 1982;32:374-8.

7. Mazzone A, Catalani M, Costanzo M, others. J Int Med Res 1990;18:379-88.

8. Jadav SP, Patel NH, Shah TG, others. J Pharmacol Pharmacother 2010;1:116-7.

9. Nakamura S, Hashimoto Y, Mikami M, others. Respirology 2003;8:316-20.

FAQ's
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Q1.	The Serrapeptase enzyme comes from the silk worm, do you have to kill many silk worms to get to the enzyme?
A1.	The bacteria from which the enzyme is isolated was first found in the digestive tract of the Japanese silkworm. The enzyme is isolated from the bacteria and produced through a fermentation process. No silkworms are harmed in the process.

Q2.	What is modified cellulose and is it safe?
A2.	The cellulose is derived from alpha cellulose from softwood pulp. This softwood pulp may be derived from hemlock, spruce or other soft woods. It is made by cooking raw plant fiber in an aqueous solution to separate the cellulose, and then purified. It then goes through extra processing to further break down the fiber. The finished product contains no residual solvents. Excipients are needed to make the materials flow into the capsule and are extremely minute in amounts and are safe.

Q3.	I am somewhat confused on how to take the DRB products. On many of the labels the Suggested Adult Use will list something along the lines of: Take 2 capsules daily, but it does not state whether they should be taken together or separately. What is the correct usage?
A3.	Unless otherwise specified on the label, the product may be taken together or separately.

Q4.	Is there a limit to how many vitamins can be taken safely in one day?
A4.	While our bodies need vitamins and minerals, like other things, if taken in large amounts they may adversely affect health. Large amounts of anything can be toxic. It is important to follow all label directions and discuss any concerns with your physician.

Q5.	What are the other ingredients and why are they used?
A5.	These are used as flow agents and aid in the production to keep the machinery running smoothly and the capsules filling correctly. Similarly for the croscarmellose sodium, which is cellulose (sourced from the cell walls of green plants), and is used to help disintegrate the tablet in the stomach.

Q6.	What is cellulose and modified cellulose produced from?
A6.	Southern pine and spruce.

Q7.	What is the source of the cellulose found in the some of the Doctor’s Best products?
A7.	The cellulose is made from alpha cellulose from softwood pulp. This softwood pulp may be derived from hemlock, Spruce or other soft woods.

Q8.	Since Doctor's Best does not manufacture its supplements, how are the purity and integrity of supplements verified? In addition, how are your prices lower than other brands? Does this mean that quality is being compromised?
A8.	Doctor's Best supplements are manufactured in the US at cGMP (current Good Manufacturing Practice) certified facilities. All of our manufacturers and suppliers go through our vendor qualification program, which includes inspections and testing, before we agree to work with them. Our finished products have also been tested at the raw material level, in process, and as a finished product to ensure safety and quality. We place the highest importance on safety and quality and do not compromise for the sake of a better price point. The price points are lower because of production size and the overall business structure. We also place great importance on making our supplements available and affordable to those who need them most.

Q9.	What is HPLC?
A9.	HPLC stands for "High Performance Liquid Chromatography." This is an analytical lab testing method that is used to quantify the active ingredients. It is considered to be a very sensitive and accurate test. HPLC testing is a tool recognized as a quality benchmark for herbal extracts.

Q10.	Does cellulose interfere with the absorption of supplements?
A10.	Dietary fiber in general is known to change intestinal viscosity, nutrient absorption, transit time, and gut hormones. Although there is some evidence from animal studies that large amounts of cellulose in the diet (6-12% of diet) can interfere with nutrient absorption (particularly minerals), there is no evidence that the small amount in capsules interfere with nutrient absorption, as there are many pharmacokinetic studies that have been conducted with nutrients in cellulose capsules, demonstrating the ability of the nutrients to be effectively absorbed.

Q11.	Is Best Serrapeptase non-GMO?
A11.	Yes, it is non-GMO.

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