High Absorption CoQ10 w/BioPerine (200 mg) 60 Veggie Caps
Suitable for vegetarians
Science-based nutrition
Dietary supplement
Fermented Japanese CoQ10
Supports heart function and energy production in cells*
High Absorption CoQ10 contains pure, vegetarian coenzyme Q10 plus BioPerine®. CoQ10 is a nutrient that supports heart function and promotes energy production in cells. BioPerine, an standardized herbal extract derived from black pepper fruit, promotes absorption of nutrients in the GI tract. Preliminary studies have shown that BioPerine® increases CoQ10 absorption.
Suggested Adult Use: Take 1 capsule daily wth food. For maximum absorption, take with a fat-containing meal.
Supplement Facts Serving Size: 1 Capsule Serving per container: 60 servings Amount Per Serving %DV Coenzyme Q10 200 mg † ----------------------------------------------------------------------------------------- Black pepper ext. (fruit) (BioPerine®) 5 mg † ----------------------------------------------------------------------------------------- † Daily Value not established.
The black pepper fruit extract used in this product is BioPerine®, a patented standardized extract containing 95% piperine.
Contains nothing other than listed ingredients.
200mg, 60VC
High Absorption CoQ10 and Best CoQ10 products contain pure, vegetarian source Coenzyme Q10. BioPerine®, a natural extract derived from black pepper, is included in High Absorption CoQ10 as an evidence-based means of increasing nutrient absorption.1
Coenzyme Q10 is a vitamin-like nutrient central to energy production at the cellular level, essential for generating metabolic energy in the form of ATP. CoQ10 is also a versatile antioxidant, stabilizing cell membranes (helping to protect them from free radical damage) and contributing to their fluidity.2 Coenzyme Q10 levels decrease with age, a factor that may actually contribute to the aging process.3 Since food content of CoQ10 can be very low, many healthcare providers recommend supplementing with Coenzyme Q10.
Due to the extraordinary energy requirements of our hardworking heart, the highest concentration of CoQ10 is found in heart muscle tissue. Coenzyme Q10 is known to support the heart through mitochondrial bioenergetics, the process of cellular energy transformation. On top of this, CoQ10 helps to promote overall cardiovascular health by confronting oxidative stress in heart and endothelial (blood vessel wall) cells.4
In terms of bioenergetics, CoQ10 supplementation acts to preserve energy turnover in mitochondria—our cellular powerhouses—by keeping ATP synthesis at optimal levels. 5 Maintenance of normal energy utilization and supply is crucial for maintaining the cell’s ideal biochemical state. Based on results from clinical studies, researchers have concluded that some segments of the population can achieve an increase in needed ATP production in addition to other benefits from CoQ10 supplementation.6
Also in the cardiovascular realm, there has been longstanding interest in the use of Coenzyme Q10 supplementation to work against the oxidative stress that takes a toll on circulating blood lipids. In addition to reacting directly with peroxyl radicals, CoQ10 indirectly helps quench radicals by regenerating the active form of vitamin E. This type of antioxidant activity is key to enhancing the structural integrity of lipids and supporting healthy blood vessels and circulation.6
Given all of these cardiovascular findings, it may not be surprising to learn that the effect of CoQ10 on blood pressure has been a topic of scientific research since 1975. A metaanalysis of such studies noted Coenzyme Q10 supplementation as one useful and safe tool in the maintenance of a healthy blood pressure, complementing the endothelial support and antioxidant advantages it provides.7,8
Helps Replenish Losses From Statins*
Many widely used statin drugs that are taken to alter cholesterol levels also have an unfortunate nutritional side effect: they are known to deplete the body’s CoQ10 by blocking its synthesis.9 Supplemental CoQ10 can be taken in anticipation of this particular drawback, with 30 days of CoQ10 supplementation in a recent study showing positive change in undesirable effects attributed to statininduced CoQ10 disruption.10
Supports Immune Function*
When the immune system goes into battle for us, immune cells need large amounts of energy to carry out their defensive functions. Among the most metabolically active of the body’s cells, they accordingly have large requirements for CoQ10.3 Although not extensively studied in humans, there is some clinical evidence that supplementing with CoQ10 can benefit the immune response.11 Researchers suggest that these immune enhancing actions can particularly benefit elderly people, since CoQ10 production decreases with age (levels steadily fall after the age of 40).
Versatile Antioxidant Support* Regenerates Other Antioxidants in the Body*
Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin E must give up an electron, which means it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E, glutathione, and alpha-lipoic acid are key antioxidants that cycle between their oxidized and reduced forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants.
Coenzyme Q10 is a unique fat-soluble antioxidant referred to as ubiquinone —or ubiquinol in its reduced form—because it is “ubiquitous” (everywhere present), that is found in almost all living cells.12 In a randomized, double-blind, placebo-controlled study where subjects had lower than usual blood concentrations of the antioxidant vitamins A, C, E, and beta-carotene, 28 days of CoQ10 supplementation provided a significant increase in blood levels of these antioxidants, compared to placebo. Vitamin E regeneration upon administration of CoQ10 has been observed in several studies.13
The Research Keeps Moving Forward*
Beyond its essential bioenergetic actions and the fat-soluble antioxidant power it offers in helping to secure the integrity of our neurons and cardiovascular tissue, Coenzyme Q10 is being studied for several different health applications. Researchers have concluded that due to its ability to inhibit collagenase, CoQ10 can aid in the reconditioning of wrinkled skin (caused by ultraviolet-B light).4
Numerous studies have been carried out to investigate the relationship between CoQ10 and exercise, physical performance, or energy metabolism. In one such recent study, researchers looked at the effect of CoQ10 supplementation on the autonomic nervous system, which is integral to energy metabolism. They discovered that subjects administered supplemental CoQ10 experienced increased oxidation of fat (enhanced fat metabolism) during low intensity exercise. Although larger studies are needed to confirm this finding, it introduces exciting new prospects for the use of supplemental CoQ10.14
Khajuria, A., N. Thusu, and U. Zutshi, Phytomedicine, 2002. 9(3): p. 224-31.
Langsjoen, P.H. and A.M. Langsjoen, Biofactors, 1999. 9(2-4): p. 273-84.
Coenzyme Q10. Monograph. Altern Med Rev, 2007. 12(2): p. 159-68.
Littarru, G.P. and L. Tiano, Nutrition, 2010. 26(3): p. 250-4.
Sinatra, S.T., Altern Ther Health Med, 2009. 15(2): p. 48-50.
Littarru, G.P. and L. Tiano, Mol Biotechnol, 2007. 37(1): p. 31-7.
Rosenfeldt, F.L., et al., J Hum Hypertens, 2007. 21(4): p. 297-306.
Belardinelli, R., et al., Eur Heart J, 2006. 27(22): p. 2675-81.
Langsjoen, P.H. and A.M. Langsjoen, Biofactors, 2003. 18(1-4): p. 101-11.
Caso, G., et al., Am J Cardiol, 2007. 99(10): p. 1409-12.
Barbieri, B., et al., Biofactors, 1999. 9(2-4): p. 351-7.
Frei, B., M.C. Kim, and B.N. Ames, Proc Natl Acad Sci U S A, 1990. 87(12): p. 4879-83.
Singh, R.B., et al., Cardiovasc Drugs Ther, 1998. 12(4): p. 347-53.
Zheng, A. and T. Moritani, J Nutr Sci Vitaminol (Tokyo), 2008. 54(4): p. 286-90.
Does Doctor's Best CoQ10 have propyl glycol in it or is it ever around it?
A1.
No and no.
Q2.
Is Doctor's Best CoQ10 the CIS form or Trans form?
A2.
It is the preferred fermented form, which is TRANSFORM.
Q3.
After a month of using CoQ10 soft gels, the color of the soft gels began to slowly change. Is it still safe to take the product?
A3.
The gelatin used to make the soft gels is sensitive to heat and light, but this would not affect the contents of the soft gel, which in this case is CoQ10, BioPerine, etc. UNLESS the temperature got to be very hot for an extended period of time.
Q4.
Is this product's CoQ10 sourced in Japan? I'm worried about the CoQ10 from Japan being contaminated by radiation.
A4.
Yes, the CoQ10 is sourced from Japan. However, we use a very reputable supplier of CoQ10 in Japan. It is manufactured in the US and tested for radiation before entering the US. All of our vendors are qualified up front using a rigorous verification process. Furthermore, all of our products are tested for safety and potency at the raw material level, in process, and as a finished product so we can maintain certainty of safety.
Q5.
If I’m sensitive to Black Pepper, can I take BioPerine?
A5.
In very rare instances, only someone will be found to be sensitive to BioPerine.
BioPerine is a high purity compound extracted from black pepper and practically devoid other compounds of black pepper, which like safarole, are contributing to the controversy of black pepper being carcinogenic. Piperine is not a carcinogen, and at purity level of minimum 98% (BioPerine) it should not pose any concerns related to black pepper or black pepper extract (see toxicology section in our book on BioPerine).
Those people who are allergic to spices, like peppers, ginger, turmeric, should use piperine containing products with caution. The same is true with any allergen, e.g. milk products should be avoided by those allergic to milk.
The advice of nutritionists to avoid consumption of black pepper in large quantities does not prevent from obtaining benefits from 5 mg of piperine corresponding to 50 mg of black pepper (9%-10% content in raw black pepper). Especially, that our society is on average consuming daily black pepper related products in an average dose of 15-30 mg (calculated from raw black pepper in various foods) of piperine per day!!! The key for patented mechanism of piperine is to be "at the right time at the right place". In other words, to do the job of "nutritionist on call" and disappear.
Q6.
I have heard that black pepper causes Prostate problems, will BioPerine do the same?
A6.
BioPerine is an extract of black pepper. Used in supplements, the quantity ingested is very small. We usually use 1.5 to 5.0 mg per capsule or tablet. Limited studies indicate that Bioperine taken in very large amounts – in the order of magnitude of grams per day (there are 1000 mg in one gram), could lead to intestinal irritation in people sensitive to black pepper. I do not know of any studies suggesting that Bioperine taken in tiny amounts are detrimental to men suffering from prostate conditions.
Q7.
What is modified cellulose and is it safe?
A7.
The cellulose is derived from alpha cellulose from softwood pulp. This softwood pulp may be derived from hemlock, spruce or other soft woods. It is made by cooking raw plant fiber in an aqueous solution to separate the cellulose, and then purified. It then goes through extra processing to further break down the fiber. The finished product contains no residual solvents. Excipients are needed to make the materials flow into the capsule and are extremely minute in amounts and are safe.
Q8.
I am somewhat confused on how to take the DRB products. On many of the labels the Suggested Adult Use will list something along the lines of: Take 2 capsules daily, but it does not state whether they should be taken together or separately. What is the correct usage?
A8.
Unless otherwise specified on the label, the product may be taken together or separately.
Q9.
Is there a limit to how many vitamins can be taken safely in one day?
A9.
While our bodies need vitamins and minerals, like other things, if taken in large amounts they may adversely affect health. Large amounts of anything can be toxic. It is important to follow all label directions and discuss any concerns with your physician.
Q10.
What are the other ingredients and why are they used?
A10.
These are used as flow agents and aid in the production to keep the machinery running smoothly and the capsules filling correctly. Similarly for the croscarmellose sodium, which is cellulose (sourced from the cell walls of green plants), and is used to help disintegrate the tablet in the stomach.
Q11.
What is Silicon Dioxide and how is it produced?
A11.
Silicon dioxide is the most abundant mineral in the Earth’s crust, and it is found across the world in various forms. Silicon dioxide (SiO2) in its pure form is colorless to white. Precipitated synthetic amorphous silicas are obtained from a process essentially using sand.
Precipitated silica is a safe (non-crystalline) mineral. According to the relevant United States and European Union standards, precipitated silica is non-hazardous with regard to manufacture, transportation and handling. Precipitated silica is an inert powder and a certified food and feed additive.
Q12.
Should I be concerned when I see that Silicon Dioxide has been used as an excipient in DRB products?
A12.
According to numerous studies reviewed to date on this long-term Generally Recognized As Safe (GRAS) listed food additive, the following was found:
The oral toxicity in mice is greater than (>) 5 grams/kilogram of body weight (Kimmerle 1968), or greater than 350 grams in one dose in humans based on allometric comparisons between mice and humans.
A single dose of 2.5 grams of amorphous polymeric silicon dioxide to human volunteers did not significantly raise the SiO2 excretion in the urine thus suggesting poor absorption of the compound (silicon dioxide)--(Langendorf 1966). Less than one one-hundredth (1000th) of the dose was found in urine, suggesting extremely poor absorption--(Langendorf 1966).
This would suggest that there is no scientific reason to eliminate silicon dioxide as an excipient at the very low levels found in dietary supplements.
For further information re: Silicon dioxide, see "Minerals, Trace Elements and Human Health, 4th Edition."
Q13.
Why is silicon dioxide used as an excipient in DRB products?
A13.
Silicon Dioxide is commonly used as a flow agent in supplements. It also works as an anti-caking agent, and is added as an ingredient in foods, many multivitamins and mineral supplements because silicon is necessary for good health and is a necessary nutrient for the health of skin, hair, nails and bones.
Q14.
It seems that information is now out claiming that magnesium stearate is a form of, or implicated in, trans fat, which everyone now regards as being bad. Why does Doctor’s Best use magnesium stearate in its products?
A14.
Magnesium Stearate is used to work as a lubricant in the formula. Magnesium Stearate is a salt of stearic acid. Stearic acid is a saturated fatty acid. A trans fatty acid (commonly shortened to trans fat) is an unsaturated fatty acid molecule. Stearic acid, being a saturated fatty acid, is not a trans fat. The magnesium stearate used in Doctor’s Best products is vegetable sourced from palm oil.
Q15.
What kind of rice constitutes the rice powder excipient commonly used in several DRB products?
A15.
Rice Powder comes from white rice unless otherwise specified on the label.
Q16.
What is cellulose and modified cellulose produced from?
A16.
Southern pine and spruce.
Q17.
Since Doctor's Best does not manufacture its supplements, how are the purity and integrity of supplements verified? In addition, how are your prices lower than other brands? Does this mean that quality is being compromised?
A17.
Doctor's Best supplements are manufactured in the US at cGMP (current Good Manufacturing Practice) certified facilities. All of our manufacturers and suppliers go through our vendor qualification program, which includes inspections and testing, before we agree to work with them. Our finished products have also been tested at the raw material level, in process, and as a finished product to ensure safety and quality. We place the highest importance on safety and quality and do not compromise for the sake of a better price point. The price points are lower because of production size and the overall business structure. We also place great importance on making our supplements available and affordable to those who need them most.
Q18.
What is HPLC?
A18.
HPLC stands for "High Performance Liquid Chromatography." This is an analytical lab testing method that is used to quantify the active ingredients. It is considered to be a very sensitive and accurate test. HPLC testing is a tool recognized as a quality benchmark for herbal extracts.
Q19.
Does cellulose interfere with the absorption of supplements?
A19.
Dietary fiber in general is known to change intestinal viscosity, nutrient absorption, transit time, and gut hormones. Although there is some evidence from animal studies that large amounts of cellulose in the diet (6-12% of diet) can interfere with nutrient absorption (particularly minerals), there is no evidence that the small amount in capsules interfere with nutrient absorption, as there are many pharmacokinetic studies that have been conducted with nutrients in cellulose capsules, demonstrating the ability of the nutrients to be effectively absorbed.
Q20.
What is the maximum dosage for BioPerine?
A20.
Black pepper has been consumed safely for thousands of years and has been deemed GRAS (generally recognized as safe) by the FDA for the intended use as a spice. However, there are limited toxicology studies on black pepper and/or black pepper extract and limited human clinical studies as well. Therefore, it is difficult to determine an "upper limit" and none has been suggested.
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