Hyal-Joint 120C

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Code:

DRB-00194

Size:

120C

MSRP:

$ 26.99

Does Not Contain: milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, salt, or preservatives.

What is it?
Ingredients
Benefits
Safety
Scientific References

Capsule 1

Hyal-Joint ^® 120 Capsule

Science-based nutrition
Dietary supplement
Nourishes joint fluid for free and easy movement*

Hyal-Joint^® is a patent-pending extract of rooster combs composed of 60% hyaluronic acid, along with collagen and other glycosaminoglycans that form the structural components of connective tissue in joints. Essential for healthy joint function and mobility, hyaluronic acid occurs naturally in the body as a part of synovial fluid, which provides the liquid layer that cushions and lubricates joints.*

Puts the spring in your step and the bounce in your walk*

Suggested Adult Use: Take 2 capsules twice daily for one or more months, followed by 1 capsule twice daily for one or more months, followed by a maintenance dose of 1 capsule daily.

Supplement Facts
Serving Size: 2 capsules
Servings per container: 60 servings
Amount Per Serving    %DV
Hyal-Joint^® 40 mg       †
(hyaluronic acid (from rooster comb cartilage) – 24mg)
------------------------------------------------------------------------------------------------
†Daily Value not established.

Other ingredients: Rice powder, silicon dioxide, magnesium stearate (vegetable source), gelatin (capsule).

Contains nothing other than listed ingredients

20mg, 120C

Doctor's Best Supplements - Ingredients - Hyal-Joint 120C

Hyal-Joint® is a patent-pending extract of rooster combs composed of 60% hyaluronic acid along with collagen and glycosaminoglycans that form the structural components of connective tissue.

The Importance of Hyaluronic Acid

Hyaluronic acid, also known as “hyaluronan”, is a large polysaccharide (complex sugar) molecule composed of disaccharides linked together in a chain. It belongs to a family of biological compounds called “glycosaminoglycans” (GAGs). These complex, versatile molecules impart structural strength and integrity to cells while providing elasticity and lubrication to joints and other body parts. GAGs can be thought of as anatomic “glue and grease” that keep bodily structures strong, supple and moving together smoothly.

We are fluid-based organisms; the body––as any biology student knows––contains up to 70% water. Cells have a high water content along with various intracellular organelles. The extra cellular matrix itself is a water world. This non-cellular environment is highly dynamic: a complex bio-field in which cell-to-cell communication and a grand array of other biochemical functions take place.

The extra cellular matrix is also the cushioning and support for joints, the bone-to-bone connections that allow us to move. For this to work according to nature’s design, the spaces between joints need to be viscous as well as fluid; this viscosity keeps friction from building up as joints move harmoniously with each other in their life-long anatomic dance.

Hyaluronic acid (HA) is essential for this vitally important viscosity—the “slipperiness” that allows us to move freely and easily. HA is remarkably viscous: 5000 times more so than water! The synovial membrane (protective layer surrounding joints) is rich in hyaluronic acid. The pliancy and resiliency of our joints would be non-existent without HA—we’d be like the Tin Man waiting for someone to bring us an oil can. When you feel the spring in your step and the bounce in your run, thank nature for hyaluronic acid; you would never experience the joy of movement if it were not for this amazing biological substance that permeates your entire body.

Helps Maintain Healthy, Smooth Joint Function*

The effect of Hyal-Joint® on joint function and comfort in humans was studied in a pilot trial of men and women aged 40 or older. The participants were randomly assigned to take either 80 mg of Hyal-Joint® or a look-alike placebo capsule every day for eight weeks. Each participant’s joint health and function status was evaluated at the beginning of the trial, and again after four and eight weeks. Assessment was done using a self-administered questionnaire that measures 24 parameters of joint function, and a 36-question survey of physical and mental health and well-being. Statistical analysis of the data showed Hyal-Joint® to be efficacious for promoting physical function, joint comfort and quality of life.¹

Nourishes Joint Fluid for Free and Easy Movement*

As described earlier, hyaluronic acid is necessary for the synovial fluid to perform its lubricating function in joints. Studies on the intra-articular injection of hyaluronic acid into joints suggest that exogenous HA potentiates endogenous production in synovial fibroblasts (synoviocytes).² In a cell culture (in vitro) study, Hyal-Joint® effectively stimulated endogenous synthesis of hyaluronic acid in synoviocytes.³

It has been observed that an ideal content of hyaluronic acid in joints––with a concomitant retention of its elastic, lubricating benefits––occurs in tandem with optimal joint health and function.³ Joint health is inextricably linked to the amount of hyaluronic acid in synovial fluid (intra-articular content).4 In horses, Hyal-Joint® was studied for its ability to promote the hyaluronic acid concentration of joints. In a small pilot trial, oral administration of Hyal-Joint® for 60 days measurably promoted both the quantity and quality of hyaluronic acid of the tarso crural joint (the articulation between the tarsal bone of the foot and the tibia and fibula), while at the same time enhancing walking ability.⁶

Kalman DS, Heimer M, Valdeon A, others. Nutr J 2008;7:3.
Ghosh P, Guidolin D. Semin Arthritis Rheum 2002;32:10-37.
Unpublished study conducted at the Rheumatology Service Research Unit; Hopsital Juan Canalejo, L Coruña, Spain.
Miltner O, Schneider U, Siebert CH, others. Osteoarthritis Cartilage 2002;10:680-6.
Brockmeier SF, Shaffer BS. Sports Med Arthrosc 2006;14:155-62.
Martínez-Puig D, Carmona JU, Argüelles D, others. Presented at the World Congress on Osteoarthritis. Dec 6-9, 2007; Ft. Lauderdale, FL.

FAQ's
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Q1.	Is it OK to take Collagen Type 2 with Collagen Types 1 and 3, or do they compete with each other for absorption?
A1.	They do not compete. To some extent, both would be digested in the GI tract and provide building blocks to the body for connective tissue support. Type I is the most abundant collagen in the body and is in high concentrations in blood vessels, tendons, skin and muscle tissue. Type III is used by the body for quick repairs and is often a precursor to type I. Type II is the major component of hyaline cartilage in joint tissue. Taking all together would likely yield an increase in the building blocks that are needed by the body to support connective tissue in many different areas.

Q2.	How is the bacteria found in the source material (rooster cartilage) killed during the production process so that the end-product is safe for consumption?
A2.	The bactericide steps are: Enzymatic hydrolysis for more than 10 hours at 57ºC, this is like a pasteurization. Thermical treatment at 85ºC for almost half an hour. Decontamination step. Addition of Hydrogen peroxide (H₂O₂) to decontaminate the solution of HJ. Every batch is analyzed in microbiological terms.

Q3.	What are your gelatin capsules made of?
A3.	Our capsules are typical gelatin capsules, with the exception of select products now available in veggie cap form. See veggie cap listing. They are made of gelatin from cattle, like the “Knox gelatin” sold in grocery stores. The gelatin used to make Doctor’s Best’s capsules is manufactured in accordance with strict guidelines that ensure it is BSE-free. The FDA and the supplement industry approved these guidelines. Our gelatin is made only from cattle living in non-BSE countries. All Doctor’s Best capsules are in full compliance with the FDA’s September 1997 guidance for industry for “The Sourcing and Processing of Gelatin to Reduce the Potential Risk Posed by Bovine Spongiform Encephalopathy in FDA-Regulated Products for Human Use.”

Q4.	How long would it take for a CAPSULE to dissolve?
A4.	Approximately 30-45 minutes. For 2-piece gelatin capsule, the USP standard for maximum dissolution time is 45 minutes. According to one large encapsulator, gelatin capsules typically dissolve in about 30 minutes, but never more than 45 minutes. Note: Testing dissolution times of capsules and tablets at home using vinegar is not an accurate way to learn what happens to capsules and tablets in your stomach. Because stomach acid is much stronger than vinegar, capsules and tablets dissolve much faster in the stomach than in a glass of water or vinegar. Also, the stomach continually “agitates” the content much like a washing machine does.

Q5.	I am somewhat confused on how to take the DRB products. On many of the labels the Suggested Adult Use will list something along the lines of: Take 2 capsules daily, but it does not state whether they should be taken together or separately. What is the correct usage?
A5.	Unless otherwise specified on the label, the product may be taken together or separately.

Q6.	Is there a limit to how many vitamins can be taken safely in one day?
A6.	While our bodies need vitamins and minerals, like other things, if taken in large amounts they may adversely affect health. Large amounts of anything can be toxic. It is important to follow all label directions and discuss any concerns with your physician.

Q7.	What are the other ingredients and why are they used?
A7.	These are used as flow agents and aid in the production to keep the machinery running smoothly and the capsules filling correctly. Similarly for the croscarmellose sodium, which is cellulose (sourced from the cell walls of green plants), and is used to help disintegrate the tablet in the stomach.

Q8.	What is Silicon Dioxide and how is it produced?
A8.	Silicon dioxide is the most abundant mineral in the Earth’s crust, and it is found across the world in various forms. Silicon dioxide (SiO2) in its pure form is colorless to white. Precipitated synthetic amorphous silicas are obtained from a process essentially using sand. Precipitated silica is a safe (non-crystalline) mineral. According to the relevant United States and European Union standards, precipitated silica is non-hazardous with regard to manufacture, transportation and handling. Precipitated silica is an inert powder and a certified food and feed additive.

Q9.	Should I be concerned when I see that Silicon Dioxide has been used as an excipient in DRB products?
A9.	According to numerous studies reviewed to date on this long-term Generally Recognized As Safe (GRAS) listed food additive, the following was found: The oral toxicity in mice is greater than (>) 5 grams/kilogram of body weight (Kimmerle 1968), or greater than 350 grams in one dose in humans based on allometric comparisons between mice and humans. A single dose of 2.5 grams of amorphous polymeric silicon dioxide to human volunteers did not significantly raise the SiO2 excretion in the urine thus suggesting poor absorption of the compound (silicon dioxide)--(Langendorf 1966). Less than one one-hundredth (1000th) of the dose was found in urine, suggesting extremely poor absorption--(Langendorf 1966). This would suggest that there is no scientific reason to eliminate silicon dioxide as an excipient at the very low levels found in dietary supplements. For further information re: Silicon dioxide, see "Minerals, Trace Elements and Human Health, 4th Edition."

Q10.	Why is silicon dioxide used as an excipient in DRB products?
A10.	Silicon Dioxide is commonly used as a flow agent in supplements. It also works as an anti-caking agent, and is added as an ingredient in foods, many multivitamins and mineral supplements because silicon is necessary for good health and is a necessary nutrient for the health of skin, hair, nails and bones.

Q11.	It seems that information is now out claiming that magnesium stearate is a form of, or implicated in, trans fat, which everyone now regards as being bad. Why does Doctor’s Best use magnesium stearate in its products?
A11.	Magnesium Stearate is used to work as a lubricant in the formula. Magnesium Stearate is a salt of stearic acid. Stearic acid is a saturated fatty acid. A trans fatty acid (commonly shortened to trans fat) is an unsaturated fatty acid molecule. Stearic acid, being a saturated fatty acid, is not a trans fat. The magnesium stearate used in Doctor’s Best products is vegetable sourced from palm oil.

Q12.	What kind of rice constitutes the rice powder excipient commonly used in several DRB products?
A12.	Rice Powder comes from white rice unless otherwise specified on the label.

Q13.	Since Doctor's Best does not manufacture its supplements, how are the purity and integrity of supplements verified? In addition, how are your prices lower than other brands? Does this mean that quality is being compromised?
A13.	Doctor's Best supplements are manufactured in the US at cGMP (current Good Manufacturing Practice) certified facilities. All of our manufacturers and suppliers go through our vendor qualification program, which includes inspections and testing, before we agree to work with them. Our finished products have also been tested at the raw material level, in process, and as a finished product to ensure safety and quality. We place the highest importance on safety and quality and do not compromise for the sake of a better price point. The price points are lower because of production size and the overall business structure. We also place great importance on making our supplements available and affordable to those who need them most.

Q14.	What is HPLC?
A14.	HPLC stands for "High Performance Liquid Chromatography." This is an analytical lab testing method that is used to quantify the active ingredients. It is considered to be a very sensitive and accurate test. HPLC testing is a tool recognized as a quality benchmark for herbal extracts.

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The Importance of Hyaluronic Acid

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