Benfotiamine 150 + Alpha-Lipoic Acid 300

60 Veggie Caps

DRB-00251

Health interest: Blood Sugar Support
  • Doctor’s Best Benfotiamine + Alpha-Lipoic Acid helps maintain healthy cells in the presence of blood glucose and provides support against oxidative stress and supports healthy aging.*

  • Benfotiamine helps protect oxidative stress induced by advanced glycation end-products.

  • Alpha-Lipoic Acid supports the body’s defense against free radicals and recycles antioxidant nutrients such as Vitamin C and Vitamin E.*

  • Alpha-lipoic acid is a sulfur-containing fatty acid that performs vitamin-like roles in the body. Because it is soluble in both water and fat, alpha-lipoic acid is sometimes referred to as the "universal antioxidant".

  • Non-GMO, Gluten Free, Vegetarian, Vegan

Available Sizes

60 Veggie Caps

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What is Doctor’s Best Benfotiamine + Alpha-Lipoic Acid?

Benfotiamine (S-benzoylthiamine-O-monophosphate) is a synthetic derivative of thiamin (vitamin B1). Benfotiamine is fat-soluble, more bioavailable, and physiologically active than thiamin.* Benfotiamine helps maintain healthy cells in the presence of blood glucose, supports against oxidative stress, and supports healthy aging. Alpha-Lipoic Acid supports the body’s defense against free radicals and recycles antioxidant nutrients such as vitamin C and vitamin E.* Alpha-lipoic acid is a sulfur-containing fatty acid, it is soluble in both water and fat and is sometimes referred to as the "universal antioxidant".

How it works?

Benfotiamine raises the blood level of thiamin pyrophosphate, the biologically active coenzyme of thiamin, and stimulates transketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways. Benfotiamine was shown to cause, on average, a 5-fold greater increase in blood thiamin levels than thiamin mononitrate, with a concomitant greater thiamin concentration in red blood cells. Benfotiamine readily passes through intestinal cells and is converted into thiamin. Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose for energy production. Aging is accompanied by a decreased ability of the liver to recycle ascorbic acid following oxidative stress. R-lipoic acid, after two weeks of supplementation to aged rats, reversed the age-related impairment of ascorbic acid recycling and concentration in liver cells. Aging is associated with oxidative stress in the brain. The brain's high rate of metabolism and its long-lived neurons make it particularly vulnerable to oxidative stress. Since alpha-lipoic acid interrupts cellular oxidative processes in both its oxidized and reduced forms, it plays a modulatory role in the brain and nervous system.

Is Benfotiamine a coenzyme?

Benfotiamine is converted into coenzyme thiamine-diphosphate (TDP) once in the body.

Is Benfotiamine derived from garlic?

No, Benfotiamine is a fat-soluble derivative of Vitamin B1, produced through synthesis.

Is the Alpha Lipoic Acid natural or synthetic and how is Alpha Lipoic Acid made?

It is synthetic.

When ALA (Alpha Lipoic Acid) is manufactured synthetically, it occurs as a racemic mixture of the 2 forms, R and S. The R form is found naturally in the body and is considered the "active" form.   Most basic ALA products are a 50:50 mixture of both R&S forms.

What is the percent of R-form and S-form in the Alpha Lipoic Acid that Doctor's Best uses?

It contains 50% R-form and 50% S-form.

What's the difference between Benfotiamine and plain old Vitamin B1?

Benfotiamine is an analog of thiamin (Vitamin B1). However, when we take supplemental thiamin, the absorption and metabolism is limited. By increasing the relative levels of thiamin in the body, Benfotiamine enhances enzyme activity that inhibits the production of advanced glycation end products (AGEs). Studies suggest an ability of benfotiamine to help maintain normal blood vessel and nerve structure.

What is the country of origin for Doctor's Best products?

Doctor’s Best products are quality tested and manufactured in the United States using highly qualified cGMP manufacturers and raw material ingredients. Doctor’s Best sources raw materials from around the world and ingredients are subject to the intense testing and verification regardless of geography of origin.

Consult your healthcare provider before use if you are taking any prescription medications or if you have a medical condition.

Information

What is Doctor’s Best Benfotiamine + Alpha-Lipoic Acid?

Benfotiamine (S-benzoylthiamine-O-monophosphate) is a synthetic derivative of thiamin (vitamin B1). Benfotiamine is fat-soluble, more bioavailable, and physiologically active than thiamin.* Benfotiamine helps maintain healthy cells in the presence of blood glucose, supports against oxidative stress, and supports healthy aging. Alpha-Lipoic Acid supports the body’s defense against free radicals and recycles antioxidant nutrients such as vitamin C and vitamin E.* Alpha-lipoic acid is a sulfur-containing fatty acid, it is soluble in both water and fat and is sometimes referred to as the "universal antioxidant".

How it works?

Benfotiamine raises the blood level of thiamin pyrophosphate, the biologically active coenzyme of thiamin, and stimulates transketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways. Benfotiamine was shown to cause, on average, a 5-fold greater increase in blood thiamin levels than thiamin mononitrate, with a concomitant greater thiamin concentration in red blood cells. Benfotiamine readily passes through intestinal cells and is converted into thiamin. Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose for energy production. Aging is accompanied by a decreased ability of the liver to recycle ascorbic acid following oxidative stress. R-lipoic acid, after two weeks of supplementation to aged rats, reversed the age-related impairment of ascorbic acid recycling and concentration in liver cells. Aging is associated with oxidative stress in the brain. The brain's high rate of metabolism and its long-lived neurons make it particularly vulnerable to oxidative stress. Since alpha-lipoic acid interrupts cellular oxidative processes in both its oxidized and reduced forms, it plays a modulatory role in the brain and nervous system.

Supplemental Facts

FAQs

Is Benfotiamine a coenzyme?

Benfotiamine is converted into coenzyme thiamine-diphosphate (TDP) once in the body.

Is Benfotiamine derived from garlic?

No, Benfotiamine is a fat-soluble derivative of Vitamin B1, produced through synthesis.

Is the Alpha Lipoic Acid natural or synthetic and how is Alpha Lipoic Acid made?

It is synthetic.

When ALA (Alpha Lipoic Acid) is manufactured synthetically, it occurs as a racemic mixture of the 2 forms, R and S. The R form is found naturally in the body and is considered the "active" form.   Most basic ALA products are a 50:50 mixture of both R&S forms.

What is the percent of R-form and S-form in the Alpha Lipoic Acid that Doctor's Best uses?

It contains 50% R-form and 50% S-form.

What's the difference between Benfotiamine and plain old Vitamin B1?

Benfotiamine is an analog of thiamin (Vitamin B1). However, when we take supplemental thiamin, the absorption and metabolism is limited. By increasing the relative levels of thiamin in the body, Benfotiamine enhances enzyme activity that inhibits the production of advanced glycation end products (AGEs). Studies suggest an ability of benfotiamine to help maintain normal blood vessel and nerve structure.

What is the country of origin for Doctor's Best products?

Doctor’s Best products are quality tested and manufactured in the United States using highly qualified cGMP manufacturers and raw material ingredients. Doctor’s Best sources raw materials from around the world and ingredients are subject to the intense testing and verification regardless of geography of origin.

Safety

Consult your healthcare provider before use if you are taking any prescription medications or if you have a medical condition.